P. Xiao

Five-layered robot (F-robot) based on functionally graded multilayer foam antiviral low-carbon (F-MAX) system for Pathogenic Microorganism Elimination

The paper introduces an air filtration system using a multilayer composite with antiviral and antibacterial properties, suitable for both commercial and residential environments.

Force sensing GPR133 is essential for normal balance and modulates vestibular hair cell membrane excitability via Gi signaling and CNGA3 coupling

This study identifies GPR133 as a force-sensing GPCR essential for balance, showing it modulates vestibular hair cell excitability via Gi signaling and CNGA3 coupling.

Soil intake modifies the gut microbiota and alleviates ovalbumin-induced mice asthma inflammation

The paper shows that sterilized soil intake reduces asthma inflammation in mice by altering gut microbiota and shifting immune responses toward Th1.

Sterile Soil as Prebiotics Mitigate Intergenerational Loss of Gut Microbial Diversity and Anxiety-Like Behavior Induced by Antibiotics in mice

This study shows that sterile soil prebiotics can restore gut microbial diversity and alleviate anxiety-like behavior and intestinal barrier issues caused by antibiotic exposure across generations in mice.

Skin mesenchymal niches maintain and protect AML-initiating stem cells

The paper shows skin mesenchymal niches protect AML-initiating stem cells from chemotherapy and promote chemoresistance in a mouse model.

Salicin modifies osteoarthritis progression by binding on IRE1α and inhibiting IRE1α mediated endoplasmic reticulum stress

Soil causes gut microbiota to flourish and total serum IgE levels to decrease in mice

The study shows that soil intake in mice increases gut microbial diversity and reduces serum IgE levels, suggesting potential prebiotic effects.

PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates

This study identifies how PTP-MEG2 regulates exocytosis by dephosphorylating specific sites on NSF, DYNAMIN2, and MUNC18-1, revealing distinct structural mechanisms for substrate recognition.

The COP9 Signalosome Suppresses Cardiomyocyte Necroptosis

This study shows that Cops8/CSN deficiency in cardiomyocytes leads to necroptosis via the RIPK1-RIPK3 pathway, with Nrf2 and redox stress playing key roles.

Structural basis of bile acid receptor activation and Gs coupling

The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.

A Genetically Encoded Trimethylsilyl 1D 1H-NMR Probe for Conformation Change in Large Membrane Protein Complexes

The paper introduces a genetically encoded 1D 1H-NMR probe for studying conformational changes in large membrane protein complexes, demonstrating its effectiveness with minimal protein and time.

Extensive adaptive immune response of AAVs and Cas proteins in non-human primates

The paper investigates pre-existing adaptive immune responses to CRISPR Cas proteins and AAVs in non-human primates and finds such immunity is普遍存在 regardless of Cas proteins or AAVs.