Author

F. Sicheri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Assay:organoid / primary culture· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

S. Orlicky· 2 shared A. A. Kossiakoff· 1 shared A. Ernst· 1 shared A. U. Singer· 1 shared B. M. Grebbin· 1 shared D. Ceccarelli· 1 shared D. Evans· 1 shared D. Y. Mao· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

S. Orlicky

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Engineered Antigen-Binding Fragments for Enhanced Crystallisation of Antibody:Antigen Complexes

H. A. Bruce, A. U. Singer, E. V. Filippova, L. L. Blazer, J. J. Adams, L. Enderle, M. Ben-David, E. H. Radley, D. Y. Mao, V. Pau, S. Orlicky, F. Sicheri, I. Kourinov, S. Atwell, A. A. Kossiakoff, S. S. Sidhu

This study identifies surface substitutions that enhance the crystallisation of Fab:antigen complexes by combining surface entropy reduction with phage-display technology and previously reported substitutions.

bioRxiv · Jul 6, 2023 · PreprintBiochemistry

SCF-FBXW7 regulates G2-M progression through control of CCNL1 ubiquitination

S. O'Brien, S. Kelso, Z. Steinhart, S. Orlicky, M. Mis, Y. Kim, S. Lin, F. Sicheri, S. Angers

This study identifies CCNL1 as a new substrate of SCF-FBXW7 and shows its role in regulating G2-M progression through ubiquitination, revealing a potential therapeutic target in cancer.

bioRxiv · Sep 26, 2022Cancer Biology

Novel Conformation Specific Inhibitors of Activated GTPases reveal Ras-dependency of Patient-Derived Cancer Organoids

S. Wiechmann, P. Maisonneuve, B. M. Grebbin, M. Hoffmeister, M. Kaulich, H. Clevers, K. Rajalingam, I. Kurinov, H. F. Farin, F. Sicheri, A. Ernst

The paper develops RBD variants that inhibit Ras effector binding, inducing senescence in non-tumorigenic cells and revealing Ras dependency in cancer organoids.

bioRxiv · Aug 28, 2019Cancer Biology

Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay

J. Koszela, N. Pham, D. Evans, S. Mann, I. Perez-Pi, S. Shave, D. Ceccarelli, F. Sicheri, M. Tyers, M. Auer

This paper introduces a fluorescent confocal on-bead assay to real-time track ubiquitination cascades and identifies new inhibitor activities against Ube1.

bioRxiv · Feb 21, 2018Biochemistry