A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification
J. Z. Zhou, B. Pei, G. Sun, M. Pawlitz, W. Zhang, x. Li, F. Yao, K. C. Hokynar, C.-X. Li, M. L. Perera, S. Wei, S. Zheng, L. A. Polin, J. M. Poulik, A. Ranki, , K. Chen
This study identifies AIRE as a checkpoint in germinal center B cells that limits antibody diversification by inhibiting AID function, leading to autoimmunity and impaired immune responses.
bioRxiv · Jan 10, 2024 · PreprintImmunology