Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization
K. K. Jang, T. Heaney, M. London, Y. Ding, F. Yeung, D. Ercelen, Y.-H. Chen, J. Axelrad, S. Gurunathan, A. M. Keestra-Gounde, M. E. Griffin, H. C. Hang, K. Cadwell
The paper shows that overproduction of REG3 proteins in IBD flares reduces Enterococcus faecium, worsening inflammation by disrupting microbiota-immune interactions.
bioRxiv · Jan 29, 2023 · PreprintImmunology