Author

D. Ercelen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:metagenomics· 2

Frequent Co-Authors

K. Cadwell· 4 shared A. Lejeune· 2 shared C. Zhou· 2 shared K. K. Jang· 2 shared P. Loke· 2 shared S. Gurunathan· 2 shared A. Korman· 1 shared A. M. Keestra-Gounde· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersImmunology

K. Cadwell

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent

A. Lejeune, C. Zhou, D. Ercelen, G. Putzel, X. Yao, A. R. Guy, M. Pawline, M. Podkowik, A. Pironti, V. J. Torres, B. Shopsin, K. Cadwell

This study shows female mice clear MRSA from the gut faster than males, relying on gut microbiota and Th17 cells, while ovariectomy reduces this resistance.

bioRxiv · Jul 17, 2024Immunology

Tofacitinib uptake by patient-derived intestinal organoids predicts individual clinical responsiveness

K. K. Jang, D. Ercelen, J. Y. C. Cen Feng, S. Gurunathan, C. Zhou, A. Korman, L. Newell, D. Hudesman, D. R. Jones, P. Loke, J. E. Axelrad, K. Cadwell

This study uses patient-derived intestinal organoids to predict individual clinical responsiveness to tofacitinib in ulcerative colitis by assessing drug sensitivity and MATE1 expression.

bioRxiv · Mar 2, 2024Cell Biology

Functional characterization of helminth-associated Clostridiales reveals covariates of Treg differentiation

S. Sargsian, A. Lejeune, D. Ercelen, W.-B. Jin, A. Varghese, P. Loke, Y. A. L. Lim, C.-J. Guo, K. Cadwell

The paper characterizes functional properties of helminth-associated Clostridiales bacteria and identifies their role in promoting Treg differentiation and Trichuris egg hatching.

bioRxiv · Jun 5, 2023Microbiology

Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization

K. K. Jang, T. Heaney, M. London, Y. Ding, F. Yeung, D. Ercelen, Y.-H. Chen, J. Axelrad, S. Gurunathan, A. M. Keestra-Gounde, M. E. Griffin, H. C. Hang, K. Cadwell

The paper shows that overproduction of REG3 proteins in IBD flares reduces Enterococcus faecium, worsening inflammation by disrupting microbiota-immune interactions.

bioRxiv · Jan 29, 2023 · PreprintImmunology