D. Mucida

Suppression of epithelial proliferation and tumorigenesis by immunoglobulin A

This study shows that IgA suppresses epithelial proliferation and tumorigenesis by interacting with DMBT1, highlighting its role in maintaining mucosal homeostasis.

Dietary protein shapes the profile and repertoire of intestinal CD4+ T cells

This study shows dietary proteins influence intestinal CD4+ T cell profiles and receptor repertoires, affecting their transcriptional programs and responses to food antigens.

Universal recording of cell-cell contacts in vivo for interaction-based transcriptomics

The paper introduces uLIPSTIC, a universal method to record cell-cell interactions in vivo, and combines it with single-cell transcriptomics to study immune cell interactions with intestinal epithelial cells.

Identification of dendritic cell-T cell interactions driving immune responses to food

This study identifies dendritic cell subsets that drive immune responses to dietary antigens, showing that cDC1s induce regulatory T cells while cDC2s promote pro-inflammatory responses.

A tissue injury repair pathway distinct but parallel to host pathogen defense

This study identifies IL24 as a tissue repair pathway parallel to IFN-mediated host defense, showing its role in epithelial and mesenchymal regeneration after injury.

Vγ usage distinguishes pro- and anti-tumor intestinal γδ T cell subsets

The paper identifies Vγ1+ and Vγ7+ γδ T cells as anti-tumor and RORγt+ subsets, including Vγ4+ and Vγ6+, as pro-tumor in colorectal cancer.

Newly recruited intraepithelial Ly6A+CCR9+CD4+ T cells protect against enteric viral infection

The paper identifies Ly6A+CCR9+CD4+ T cells in the intestinal epithelium that protect against enteric viral infections through IFN-gamma-dependent mechanisms.

Enteric pathogens induce tissue tolerance and prevent neuronal loss from subsequent infections

This study shows that enteric pathogens induce tissue tolerance mechanisms that prevent neuronal loss and gut motility disruption during subsequent infections.

c-MAF dependent perivascular macrophages regulate diet induced metabolic syndrome

This study identifies c-MAF-dependent perivascular macrophages and shows their role in regulating metabolic syndrome through altered gene expression and vascular changes in response to high-fat diet.

Antigen-specific induction of CD4+CD8αα+ intraepithelial T lymphocytes byBacteroidetes species

This study identifies Bacteroidetes species that induce CD4+CD8αα+ intraepithelial T lymphocytes, which provide protective immunity against colitis.

Stepwise chromatin and transcriptional acquisition of an intraepithelial lymphocyte program

The paper investigates how T cells adapt transcriptionally and chromatinally when migrating to intestinal compartments, showing a stepwise replacement of their original program with site-specific changes.

T cell receptor is required for differentiation but not maintenance of intestinal intraepithelial lymphocytes

Adrenergic signaling in muscularis macrophages limits neuronal death following enteric infection

The paper investigates how enteric infections affect enteric neurons and shows that intestinal muscularis macrophages use β2-adrenergic receptor signaling to protect neurons via an arginase 1-polyamine axis.

Vasculature-associated adipose tissue macrophages dynamically adapt to inflammatory and metabolic challenges

The paper identifies vasculature-associated adipose tissue macrophages (VAMs) and shows how they adapt to metabolic and inflammatory challenges in epididymal white adipose tissue.

Compartmentalized lymph node drainage dictates intestinal adaptive immune responses

This study shows that mesenteric lymph nodes (mLNs) along the intestine are functionally distinct, with proximal mLNs promoting tolerance and distal mLNs driving inflammation, and demonstrates how disruptions in this compartmentalization affect immune responses.

Intestinal epithelial and intraepithelial T cell crosstalk mediates a dynamic response to infection

The paper investigates how intestinal epithelial cells and T cells interact during infection, showing that microbial sensing alters T cell behavior and metabolism to protect the intestinal barrier.

Tissue adaptation: implications for gut immunity and tolerance

This review discusses how immune cells adapt to the gut mucosa, focusing on their ability to distinguish between harmless microbiota and pathogens, and how tissue factors influence immune cell function and fate.