S. Lai

Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progression

The paper analyzes paired breast carcinomas to determine if recurrences are clonal or new tumors, finding 7% are non-clonal by whole exome sequencing.

Disorganization of basement membrane zone architecture causes impaired melanocyte inhabitation in vitiligo

This study identifies disorganized basement membrane zone architecture and MMP2 overexpression in dermal fibroblasts as contributors to melanocyte loss in vitiligo.

Design of a systemic small molecule clinical STING agonist using physics-based simulations and artificial intelligence

This paper designs a small molecule STING agonist, SNX281, using computational methods and AI, showing systemic activity and antitumor effects in mice.

Proteolysis Targeting Chimeras With Reduced Off-targets

This study develops a platform to identify off-target degradation of ZF proteins by PROTACs and identifies design rules to reduce off-target effects using pomalidomide analogs.

Nuclear damage in LMNA mutant iPSC-derived cardiomyocytes is associated with impaired lamin localization to the nuclear envelope

This study shows that LMNA mutations in iPSC-derived cardiomyocytes cause nuclear shape changes, reduced stiffness, and lamin mislocalization, linking nuclear abnormalities to LMNA-DCM pathogenesis.

Cryo-EM structures of human TMEM120A and TMEM120B

The paper reports cryo-EM structures of human TMEM120A and TMEM120B, revealing similar dimeric assemblies but no structural basis for their differing mechanosensing properties.

Single-cell transcriptomics reveals zone-specific alterations of liver sinusoidal endothelial cells in cirrhosis

This study uses single-cell RNA sequencing to identify zone-specific transcriptomic changes in liver sinusoidal endothelial cells in cirrhosis, revealing Zone 3 LSECs as most susceptible to damage.

FoxMask: a new automated tool for animal detection in camera trap images

FoxMask automatically detects animal presence in camera trap images, achieving >90% accuracy and reducing manual analysis workload.

Antibody-mediated immobilization of virions in mucus

This study analyzes virion movement in mucus using single-particle tracking to show how antibodies immobilize virions through cooperative binding and entanglement with mucin.

Phylogenetic relationships in the genus Avena based on the nuclear Pgk1 gene

The paper investigates phylogenetic relationships among Avena taxa using the Pgk1 gene, revealing structural divergence and evolutionary relationships between genomes.