Cycling cancer persister cells arise from lineages with distinct transcriptional and metabolic programs
Y. Oren, M. Tsabar, H. F. Cabanos, M. S. Cuoco, E. Zaganjor, P. I. Thakore, M. Tabaka, C. P. Fulco, S. A. Hurvitz, D. J. Slamon, G. Lahav, A. Hata, J. S. Brugge, A. Regev
The paper identifies cycling cancer persisters with distinct transcriptional and metabolic programs using a new tracing system and shows that targeting oxidative stress or metabolic reprogramming reduces their fraction.
bioRxiv · Jun 5, 2020Cancer Biology