GSK3α/β restrains IFNγ-inducible costimulatory molecule expression in alveolar macrophages, limiting CD4+ T cell activation
L. M. Ankley, K. N. Conner, T. E. Vielma, M. Thapa, A. J. Olive
bioRxiv · Aug 16, 2023 · PreprintImmunology
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M. Thapa
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2021-2023 · peak 3/yrCo-Author Collaboration Network
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Recent·Most cited
Germinal centre-driven maturation of B cell response to SARS-CoV-2 vaccination
W. Kim, J. Q. Zhou, A. J. Sturtz, S. C. Horvath, A. J. Schmitz, T. Lei, E. Kalaidina, M. Thapa, W. B. Al Soussi, A. Haile, M. K. Klebert, T. Suessen, L. Parra-Rodriguez, P. A. Mudd, W. D. Middleton, , A. H. Ellebedy
This study tracks the maturation of B cell responses to SARS-CoV-2 vaccination, showing that memory B cells and bone marrow plasma cells accumulate somatic hypermutations over time, enhancing antibody avidity.
bioRxiv · Oct 31, 2021 · PreprintImmunology
PcGCE is a potent elicitor of defense responses in aspen
E. N. Donev, M. Derba-Maceluch, X. Liu, H. C. Bwanika, I. Dobrowolska, M. Thapa, J. Lesniewska, J. Simura, A. Y.- L. Tsai, D. Boström, L. A. Kleczkowski, M. E. Eriksson, K. Ljung, E. R. Master, E. J. Mellerowicz
This paper shows that PcGCE, a microbial enzyme, acts as a pathogen-associated molecular pattern in aspen, triggering immune responses and growth retardation when expressed in transgenic plants.
bioRxiv · Sep 23, 2021 · PreprintBioengineering
A public vaccine-induced human antibody protects against SARS-CoV-2 and emerging variants
A. J. Schmitz, J. S. Turner, Z. Liu, I. D. Aziati, R. E. Chen, A. Joshi, T. L. Bricker, T. L. Darling, D. C. Adelsberg, W. B. Al Soussi, J. B. Case, T. Lei, M. Thapa, F. Amanat, J. A. O'Halloran, , A. H. Ellebedy
A vaccine-induced human monoclonal antibody neutralizes SARS-CoV-2 and variants, reducing lung inflammation and viral load in hamsters.
bioRxiv · Mar 24, 2021Immunology