M. Tokunaga

This study shows that mismatch between viral antigen epitopes and T-cell responses in HTLV-1 infection may reduce immunotherapy effectiveness against ATL.

This study identifies importin-7 as a nuclear carrier for Flaviviridae core proteins and shows its requirement for infectious virus production.

Slitflow is a Python framework for single-molecule dynamics and localization analysis, offering a flexible workflow for image processing, dynamics analysis, and figure creation.

The paper identifies AHDC1 as a protein interacting with EWS-FLI1 in Ewing's sarcoma and shows its knockdown reduces cell growth and transcriptional activity.

This study uses single-cell RNA-Seq and TCR-Seq to show HTLV-1-infected T-cells transition into highly activated ATL cells with Treg signatures and upregulated HLA class II, enabling immune evasion.

The paper introduces a method to visualize two endogenous chromatin loci in living cells using synthetic zinc-finger proteins and frankenbodies, revealing their dynamic association and separation upon cohesin disruption.

The paper develops a genetically encoded probe to detect elongating RNA polymerase II in living cells and shows its foci move more dynamically than chromatin domains.

This study identifies USP15 as a host factor for HCV propagation, showing it regulates viral RNA translation and lipid droplet formation in hepatic cells.