Y. Matsuura

This study identifies CB1 receptor antagonists as inhibitors of Lujo virus entry by suppressing viral membrane fusion and reducing infectivity in vitro.

This study shows that typhoon-induced Lammas growth in host plants allows the Great Orange Tip butterfly subspecies cincia to avoid dormancy by providing winter food, altering population dynamics in the Ryukyu Islands.

This study identifies AS1-S, a BLV-derived lncRNA, as a regulator of hnRNPM interactions with host mRNAs, potentially influencing BLV pathogenesis and tumor progression.

This paper shows an engineered ACE2 decoy neutralizes Omicron subvariants and is effective in treating SARS-CoV-2 infection in macaques.

This study identifies 2-thiouridine as a broad-spectrum antiviral against SARS-CoV-2 and other positive-strand RNA viruses by inhibiting viral RNA synthesis.

This study shows that SARS-CoV-2 ORF8 protein acts as a cytokine that promotes lung inflammation and immune dysregulation in COVID-19, suggesting it as a potential therapeutic target.

This study identifies remdesivir-resistant SARS-CoV-2 mutations using viral reconstruction, mathematical modeling, and molecular dynamics simulations, showing mutations reduce antiviral activity without increasing viral production.

The paper shows the Delta variant can escape NTD antibodies and gain infectivity when specific RBD mutations are present, suggesting the need for updated vaccines.

This study identifies two SARS-CoV-2 mutations, L452R and Y453F, that evade HLA-restricted cellular immunity and increase viral infectivity.

This study develops a live attenuated SARS-CoV-2 vaccine platform using temperature-sensitive mutations that provides protection against homologous and heterologous viral challenges.

This study evaluates a plasmid DNA vaccine against SARS-CoV-2 using a pyro-drive jet injector, showing strong immune response and protection in rodents.

The paper investigates how mutations in the nsp14 gene of SARS-CoV-2 affect genomic diversity and evolution, finding that the P203L mutation increases evolutionary rate and genomic variation.

This study identifies an NTD site on SARS-CoV-2 spike protein that enhances infectivity when targeted by antibodies, and finds these antibodies are present in hospitalized patients and some uninfected donors.

This study identifies L-SIGN and DC-SIGN as receptors for the N-terminal domain of SARS-CoV-2 spike protein, showing their role in infection and the importance of anti-NTD antibodies.

This study evaluates a DNA vaccine targeting SARS-CoV-2 Spike protein, showing enhanced humoral and cellular immune responses and neutralizing antibody activity.

This study develops a PCR-based reverse genetics system for SARS-CoV-2 using CPER to generate infectious clones with high accuracy and titer.

Passive head motion reduces blood pressure in hypertensive rats and humans by decreasing AT1R expression in RVLM astrocytes through interstitial fluid shear stress.

The paper engineers high-affinity ACE2 receptors to neutralize SARS-CoV-2 in hamsters, showing protection against infection without viral escape mutations.

This study analyzes B cell epitopes and neutralizing activity in COVID-19 patients to identify potential vaccine targets.

This study identifies miRNAs other than miR-122 that support HCV replication in non-hepatic cells by interacting with the viral 5UTR and stabilizing the IRES structure.

This study demonstrates that delivering mesenchymal stem cells (MSCs) in a collagen gel scaffold enhances their migration to damaged sites and promotes wound healing without systemic side effects.

This study identifies USP15 as a host factor for HCV propagation, showing it regulates viral RNA translation and lipid droplet formation in hepatic cells.