Author

M. Woo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 3 Research Focus:drug response / drug discovery· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:statistical model· 2 Organism:virus· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. N. Septer· 2 shared I. Jurisica· 2 shared L. Speare· 2 shared M. Kotlyar· 2 shared A. B. Dart· 1 shared A. Biankin· 1 shared A. Boshart· 1 shared A. d. M. Czeczot· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersMicrobiology

A. N. Septer

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Flagella are required to coordinately activate competition and host colonization factors in response to a mechanical signal

L. Speare, L. Zhao, M. N. Pavelsky, A. Jackson, S. Smith, B. Tyagi, G. C. Sharpe, M. Woo, L. Satkowiak, T. Bolton, S. M. Gifford, A. N. Septer

This study identifies flagella as mechanosensors in Vibrio fischeri that coordinate activation of competition and host colonization factors in response to viscosity changes.

bioRxiv · Dec 31, 2023 · PreprintMicrobiology

Identification and characterization of new structural scaffolds modulating the activity of Mycobacterium tuberculosis dihydroneopterin aldolase (FolB) in vitro

V. C. d. A. Falcao, A. d. M. Czeczot, M. M. Alam, K.-H. P. Park, J. Heo, M. Woo, A. M. Camini, L. F. S. M. Timmers, D. Shum, M. A. Perello, L. A. Basso, P. Machado, C. V. Bizarro, V. P. Delorme

The paper identifies and characterizes new structural scaffolds that modulate the activity of Mycobacterium tuberculosis dihydroneopterin aldolase (FolB) in vitro, finding compounds with IC50 values ranging from 2.6 to 47 μM.

bioRxiv · Nov 21, 2023 · PreprintBiochemistry

B Cells Promote T Cell Immunosenescence and Mammalian Aging Parameters

S. Khan, M. Chakraborty, F. Wu, N. Chen, T. Wang, Y. T. Chan, A. Sayad, J.-D. S. Vasquez, M. Kotlyar, K. Nguyen, Y. Huang, F. J. Alibhai, M. Woo, R.-K. Li, M. Husain, , D. A. Winer

The paper identifies B cells as drivers of T cell immunosenescence and aging, showing that targeting B cells with CD20 antibodies can reverse age-related T cell dysfunction.

bioRxiv · Sep 12, 2023 · PreprintImmunology

Cell Sex and Sex Hormones Modulate Kidney Glucose and Glutamine Metabolism in Health and Diabetes

S. Clotet-Freixas, O. Zaslaver, C. Pastrello, M. Kotlyar, C. M. McEvoy, S. Farkona, A. Saha, A. Boshart, M. Chan, M. Riera, M. J. Soler, A. Isenbrandt, J. Lamontagne-Proulx, S. Pradeloux, K. Coulombe, , A. Konvalinka

This study shows that cell sex and sex hormones influence glucose and glutamine metabolism in kidney cells, with male cells showing increased metabolic stress and female cells showing better redox balance.

bioRxiv · Aug 23, 2021 · PreprintCell Biology

A large lipoprotein mediates target specificity for T6SS-dependent killing

L. Speare, M. Woo, A. K. Dunn, A. N. Septer

The paper identifies a large lipoprotein, TasL, that mediates target specificity for T6SS-dependent killing in Vibrio species by selectively aggregating competitors.

bioRxiv · Apr 26, 2021 · PreprintMicrobiology

An unbiased high-throughput drug screen reveals a potential therapeutic vulnerability in the most lethal molecular subtype of pancreatic cancer

C.-H. Pan, Y. Otsuka, B. Sridharan, M. Woo, S. Babu, C. V. Leiton, J. D. Bai, D. K. Chang, A. Biankin, L. Scampavia, T. Spicer, L. F. Escobar-Hoyos, K. R. Shroyer

This study identifies K17 as a biomarker for PDAC and shows that PPT, a microtubule inhibitor, is more effective against K17-expressing PDAC cells when combined with Gemcitabine.

bioRxiv · Oct 11, 2019Cancer Biology