Author

M. Kotlyar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

I. Jurisica· 5 shared C. Pastrello· 3 shared A. Konvalinka· 2 shared C. M. McEvoy· 2 shared J. T.-S. Chow· 2 shared L. Salmena· 2 shared M. M. Gabra· 2 shared M. Woo· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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5 shared papersImmunology

I. Jurisica

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

B Cells Promote T Cell Immunosenescence and Mammalian Aging Parameters

S. Khan, M. Chakraborty, F. Wu, N. Chen, T. Wang, Y. T. Chan, A. Sayad, J.-D. S. Vasquez, M. Kotlyar, K. Nguyen, Y. Huang, F. J. Alibhai, M. Woo, R.-K. Li, M. Husain, , D. A. Winer

The paper identifies B cells as drivers of T cell immunosenescence and aging, showing that targeting B cells with CD20 antibodies can reverse age-related T cell dysfunction.

bioRxiv · Sep 12, 2023 · PreprintImmunology

Cell Sex and Sex Hormones Modulate Kidney Glucose and Glutamine Metabolism in Health and Diabetes

S. Clotet-Freixas, O. Zaslaver, C. Pastrello, M. Kotlyar, C. M. McEvoy, S. Farkona, A. Saha, A. Boshart, M. Chan, M. Riera, M. J. Soler, A. Isenbrandt, J. Lamontagne-Proulx, S. Pradeloux, K. Coulombe, , A. Konvalinka

This study shows that cell sex and sex hormones influence glucose and glutamine metabolism in kidney cells, with male cells showing increased metabolic stress and female cells showing better redox balance.

bioRxiv · Aug 23, 2021 · PreprintCell Biology

INPP4B drives lysosome biogenesis to restrict leukemic stem cell differentiation and promote leukemogenesis

J. F. Woolley, K. Chen, G. T. Saffi, G. E. Genc, D. K. C. Lee, I. Dzneladze, R. He, J. T.-S. Chow, M. M. Gabra, M. H. Son, C. M. P. Melo, C. A. Newell, A. He, E. M. Schoof, S. Z. Xie, , L. Salmena

This study identifies INPP4B's role in promoting leukemic stem cell (LSC) survival by enhancing lysosome biogenesis, leading to poor AML prognosis and suggesting therapeutic targets.

bioRxiv · Mar 25, 2021 · PreprintCancer Biology

Autoantibodies Against Ro/SS-A, CENP-B, and La/SS-B are Increased in Patients with Kidney Allograft Antibody-Mediated Rejection

S. Clotet-Freixas, M. Kotlyar, C. M. McEvoy, C. Pastrello, S. Rodriguez-Ramirez, S. Farkona, H. Cardinal, M. Dieude, M.-J. Hebert, Y. Li, O. Famure, P. Chen, S. J. Kim, E. Chan, I. Jurisica, , A. Konvalinka

The paper identifies increased levels of specific non-HLA autoantibodies in kidney transplant patients with antibody-mediated rejection.

bioRxiv · Dec 2, 2020Immunology

Essential gene networks in acute myeloid leukemia identified using a microRNA-knockout CRISPR library screen

M. M. Gabra, C. Pastrello, N. Machado, J. T.-S. Chow, M. Kotlyar, T. Tokar, I. Jurisica, L. Salmena

The paper identifies essential miRNAs and their target genes in AML using a CRISPR screen and pathway analysis.

bioRxiv · Jun 6, 2019 · PreprintCancer Biology