M.-G. Kang

The paper shows mitochondrial thermogenesis generates heat that triggers a nuclear heat-shock response in mammalian cells.

This study shows VCP regulates FUS granule stability by consuming ATP inside the granules, acting as a timer to prevent persistent granules that lead to ALS pathology.

The paper uses a transgenic mouse model to profile mitochondrial matrix proteomes and identifies RTN4IP1/OPA10 as an antioxidant NADPH oxidoreductase involved in CoQ biosynthesis and mitochondrial function.

This study identifies ORF3a and M proteins of SARS-CoV-2 as reorganizing the endoplasmic reticulum and mitochondrial-associated membrane, with potential therapeutic implications.

The paper introduces iSLET, a method to track tissue-specific secretory proteins in live mice, demonstrating its use in labeling and identifying liver-specific secreted proteomes in blood plasma.