Author

N. Aziz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Harkess· 1 shared A. Kay· 1 shared A. M. Darnell· 1 shared B. T. Do· 1 shared C. Blish· 1 shared C. Chidley· 1 shared C. Dekker· 1 shared C. Seiler· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperEvolutionary Biology

A. Harkess

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Parameterizing Pantherinae: de novo mutation rate estimates from Panthera and Neofelis pedigrees

E. E. Armstrong, S. B. Carey, A. Harkess, G. Zenato Lazzari, K. A. Solari, J. E. Maldonado, R. C. Fleischer, N. Aziz, P. Walsh, K.-P. Koepfli, E. Eizirik, D. A. Petrov, M. Campana

The paper estimates de novo mutation rates in Panthera and Neofelis species using pedigrees, finding rates between 0.5 and 1.4e-08 per generation per base pair.

bioRxiv · Apr 6, 2024Evolutionary Biology

Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

B. T. Do, P. P. Hsu, S. Y. Vermeulen, Z. Wang, T. Hirz, K. L. Abbott, N. Aziz, J. M. Replogle, S. Bjelosevic, J. Paolino, S. Nelson, S. Block, A. M. Darnell, R. Ferreira, H. Zhang, , M. G. Vander Heiden

The paper shows that nucleotide depletion and DNA replication stress drive cell fate transitions in hematopoietic systems by activating lineage-specific maturation genes.

bioRxiv · Aug 16, 2022Cancer Biology

MyD88-Syk axis is a critical determinant for inflammatory response in macrophages

Y.-S. Yi, J. H. Kim, W. S. Yang, E. Kim, D. Jeong, J. G. Park, N. Aziz, S. Kim, N. Parameswaran, J. Y. Cho

This study shows that the MyD88-Syk axis drives inflammatory responses in macrophages by promoting ROS/RNS generation and phagocytic activity through Src, F-actin, and Rac1.

bioRxiv · Nov 15, 2019 · PreprintImmunology

CD38 contributes to human natural killer cell responses through a role in immune synapse formation

M. Le Gars, C. Seiler, A. Kay, N. Bayless, E. Sola, E. Starosvetsky, L. Moore, S. Shen-Orr, N. Aziz, C. Dekker, P. Khatri, G. Swan, M. Davis, S. Holmes, C. Blish

This study identifies CD38 as a key receptor in human NK cells that facilitates immune synapse formation, enhancing antiviral and antitumor responses.

bioRxiv · May 24, 2019 · PreprintImmunology