WWP2 MEDIATES THE METABOLIC REPROGRAMMING OF RENAL MYOFIBROBLASTS TO PROMOTE KIDNEY FIBROSIS
H. Chen, R. You, J. Guo, W. Zhou, G. Chew, N. Devapragash, J. Z. Loh, L. Gesualdo, Y. Li, Y. Jiang, E. L. S. Tan, S. Chen, P. Pontrelli, F. Pesce, J. Behmoaras, , E. G. Petretto
This paper identifies WWP2 as a regulator of myofibroblast metabolic reprogramming in renal fibrosis, showing it suppresses PGC-1 to alter metabolic pathways and reduce fibrosis severity.
Journal of the American Society of Nephrology · Mar 19, 2024Peer-reviewedCell Biology