Author

R. You

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 4 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 5 Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell signaling & trafficking· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2

Frequent Co-Authors

M. F. Krummel· 4 shared A. A. Rao· 2 shared A. J. Combes· 2 shared C. M. Hendrickson· 2 shared D. J. Erle· 2 shared K. H. Hu· 2 shared L. Rodriguez· 2 shared M. Magnen· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersImmunology

M. F. Krummel

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

WWP2 MEDIATES THE METABOLIC REPROGRAMMING OF RENAL MYOFIBROBLASTS TO PROMOTE KIDNEY FIBROSIS

H. Chen, R. You, J. Guo, W. Zhou, G. Chew, N. Devapragash, J. Z. Loh, L. Gesualdo, Y. Li, Y. Jiang, E. L. S. Tan, S. Chen, P. Pontrelli, F. Pesce, J. Behmoaras, , E. G. Petretto

This paper identifies WWP2 as a regulator of myofibroblast metabolic reprogramming in renal fibrosis, showing it suppresses PGC-1 to alter metabolic pathways and reduce fibrosis severity.

Journal of the American Society of Nephrology · Mar 19, 2024Peer-reviewedCell Biology

HCCDB v2.0: Decompose the Expression Variations by Single-cell RNA-seq and Spatial Transcriptomics in HCC

Z. Jiang, Y. Wu, Y. Miao, K. Deng, F. Yang, S. Xu, Y. Wang, R. You, L. Zhang, Y. Fan, W. Guo, Q. Lian, L. Chen, X. Zhang, Y. Zheng, J. Gu

HCCDB v2.0 integrates bulk, single-cell, and spatial transcriptomic data from HCC samples to enhance meta-analysis and provide new metrics for gene expression patterns.

Genomics, Proteomics & Bioinformatics · Feb 3, 2024Peer-reviewedCancer Biology

Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung.

K. Kersten, R. You, S. Liang, K. Tharp, J. Pollack, V. M. Weaver, M. F. Krummel, M. B. Headley

This study shows that uptake of tumor-derived microparticles by macrophages in the early metastatic lung leads to metabolic reprogramming and altered function.

bioRxiv · Nov 15, 2022Immunology

Immediate myeloid depot for SARS-CoV-2 in the human lung

M. Magnen, R. You, A. A. Rao, R. T. Davis, L. Rodriguez, C. R. Simoneau, L. Hysenaj, K. H. Hu, The UCSF COMET Consortium, C. Love, P. G. Woodruff, D. J. Erle, C. M. Hendrickson, C. S. Calfee, M. A. Matthay, , M. R. Looney

The paper investigates early SARS-CoV-2 infection in human lung myeloid cells, finding rapid viral tropism, ACE2 dependence, and poor interferon induction, suggesting a myeloid depot for viral persistence.

bioRxiv · Apr 28, 2022Immunology

Active Surveillance Characterizes Human Intratumoral T Cell Exhaustion

R. You, J. Artichoker, A. Fries, A. Edwards, A. J. Combes, G. Reeder, B. Samad, M. F. Krummel

The paper studies T cell exhaustion in human tumors using live-biopsy and two-photon microscopy, finding variable T cell speed and a link between motility and exhaustion state.

bioRxiv · May 6, 2021Immunology

Global Absence and Targeting of Protective Immune States in Severe COVID-19.

A. J. Combes, T. Courau, N. F. Kuhn, K. H. Hu, A. Ray, W. S. Chen, S. J. Clearly, N. W. Chew, D. Kushnoor, G. C. Reeder, A. Shen, J. Tsui, K. J. Hiam-Galvez, P. Munoz-Sandoval, W. S. Zhu, , M. F. Krummel

The paper identifies that severe COVID-19 patients lack ISG-expressing cells and have antibodies that block their production, contrasting with mild cases.

bioRxiv · Oct 28, 2020Immunology