Author

N. Franko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:human· 6 Assay:proteomics· 5 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. Logue· 4 shared A. C. Walls· 3 shared D. Veesler· 3 shared H. Chu· 3 shared H. Y. Chu· 3 shared J. E. Bowen· 3 shared K. R. Sprouse· 3 shared A. Addetia· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersImmunology

J. Logue

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Persistent immune imprinting after XBB.1.5 COVID vaccination in humans

M. A. Tortorici, A. Addetia, A. J. Seo, J. Brown, K. Sprouse, J. Logue, E. Clarke, N. Franko, H. Chu, D. Veesler

This study shows that immune imprinting from prior Wuhan-Hu-1 spike exposure persists after XBB.1.5 vaccine booster, with neutralizing antibodies dominated by pre-existing memory B cells.

bioRxiv · Nov 28, 2023 · PreprintImmunology

Anamnestic Humoral Correlates of Immunity Across SARS-CoV-2 Variants of Concern

R. McNamara, J. S. Maron, H. L. Bertera, J. Boucau, V. Roy, A. K. Barczak, The Positives Study Staff, N. Franko, J. Z. Li, J. S. McLellan, M. Siedner, J. E. Lemieux, H. Chu, G. Alter

The paper identifies conserved S2-domain antibody responses in anamnestic immunity across SARS-CoV-2 variants, suggesting their role in viral clearance and vaccine design.

bioRxiv · Jun 19, 2022Immunology

Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

Y.-J. Park, D. Pinto, A. C. Walls, Z. Liu, A. De Marco, F. Benigni, F. Zatta, C. Silacci-Fregni, J. Bassi, K. R. Sprouse, A. Addetia, J. E. Bowen, C. Stewart, M. Giurdanella, C. Saliba, , Piccoli

This study shows that hybrid immunity and vaccine boosters provide potent neutralizing activity against Omicron BA.1 and BA.2, while breakthrough infections induce nasal mucosal neutralization and identify an ultrapotent pan-variant antibody.

bioRxiv · May 8, 2022Immunology

The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopes

A. J. Greaney, R. T. Eguia, T. N. Starr, K. Khan, N. Franko, J. K. Logue, S. M. Lord, C. Speake, H. Y. Chu, A. Sigal, J. D. Bloom

The paper examines the antibody response to the SARS-CoV-2 Delta variant, showing it targets class 1 and 2 epitopes more than class 3, and that mutations in these regions reduce antibody binding.

bioRxiv · Mar 12, 2022Microbiology

Delta breakthrough infections elicit potent, broad and durable neutralizing antibody responses

A. C. Walls, K. R. Sprouse, A. Joshi, J. E. Bowen, N. Franko, M.-J. Navarro, C. Stewart, M. McCallum, E. A. Goecker, E. J. Degli-Angeli, J. Logue, A. Greninger, H. Chu, D. Veesler

The paper examines antibody responses in Delta breakthrough infections, finding they are more potent, durable, and broad compared to vaccinated-only or infected-only individuals.

bioRxiv · Dec 8, 2021 · PreprintImmunology

Comprehensive characterization of the antibody responses to SARS-CoV-2 Spike protein after infection and/or vaccination

M. E. Garrett, J. G. Galloway, C. Wolf, J. K. Logue, N. Franko, H. Y. Chu, F. Matsen, J. M. Overbaugh

This study characterizes antibody responses to SARS-CoV-2 Spike protein after infection and vaccination, identifying epitope binding patterns and escape mutation profiles.

bioRxiv · Oct 5, 2021Immunology

Molecular basis of immune evasion by the delta and kappa SARS-CoV-2 variants

M. McCallum, A. C. Walls, K. R. Sprouse, J. E. Bowen, L. Rosen, H. V. Dang, A. deMarco, N. Franko, S. W. Tilles, J. Logue, M. C. Miranda, M. Ahlrichs, L. Carter, G. Snell, M. S. Pizzuto, , D. Veesler

This study investigates how delta and kappa SARS-CoV-2 variants evade immune responses by altering antigenic sites and reducing ACE2 binding affinity.

bioRxiv · Aug 11, 2021Immunology