J. E. Lemieux

The paper designs SARS-CoV-2 Spike proteins with novel mutations to evaluate vaccine effectiveness against future viral variants using a deep learning model.

This study uses whole genome sequencing of Borrelia burgdorferi isolates to identify plasmid-borne accessory genome elements linked to virulence and dissemination of Lyme disease.

The paper identifies conserved S2-domain antibody responses in anamnestic immunity across SARS-CoV-2 variants, suggesting their role in viral clearance and vaccine design.

This study shows the D614G SARS-CoV-2 spike protein variant is more infectious but has reduced ACE2 affinity and altered trimer conformation, affecting viral entry and antibody neutralization.

This paper develops SHINE, a diagnostic tool for SARS-CoV-2 detection with 90% sensitivity and 100% specificity, reducing contamination risk and enabling use outside clinical settings.