J. Z. Li

This paper models viral resistance emergence in SARS-CoV-2 treated with anti-spike monoclonal antibodies, showing that target cell replenishment mechanisms can explain high viral rebounds.

The paper examines CD8+ T cells in the colon of HIV patients on ART, finding impaired mitochondrial function and reduced immune responses compared to peripheral blood cells.

This study shows that S:D614G and S:H655Y mutations enhance SARS-CoV-2 infectivity by stabilizing the Spike protein in an open RBD conformation, acting epistatically with the polybasic S1/S2 cleavage site.

This study compares the pathogenicity and immune evasion of an Omicron S-bearing virus with natural Omicron, showing vaccine escape via S mutations but severe disease due to factors outside S.

The paper identifies conserved S2-domain antibody responses in anamnestic immunity across SARS-CoV-2 variants, suggesting their role in viral clearance and vaccine design.

The paper identifies TSPAN8 as a novel mediator of SARS-CoV-2 infection in lung organoids, showing its correlation with infection rates and susceptibility to blocking antibodies.

This study identifies distinct genetic and immunologic features of recurrent stage I lung adenocarcinoma using multiomic profiling and single-cell RNA-seq.

The paper investigates sex differences in placental responses to maternal SARS-CoV-2 infection, finding sex-specific changes in interferon genes, Fc-receptor expression, and antibody transfer.

This study evaluates how between-tissue differences affect pan-cancer drug sensitivity predictions and finds that tissue-level responses are accurately predicted, but within-tissue predictions are less successful.

The paper identifies Treg cell perturbations in severe COVID-19 patients, showing increased FoxP3 levels and pro-inflammatory traits linked to disease severity.

This study links phospholipid and lysophospholipid levels to faster HIV rebound after treatment interruption, suggesting their role in viral persistence and inflammation.

The paper maps viral mutations in SARS-CoV-2 that escape two therapeutic antibodies, identifying escape mutations present in circulating strains.

This study identifies serum sphingolipids associated with insulin sensitivity using lipidomics and glucose clamp techniques, finding SM/Cer and SM d18:0/26:0 as potential biomarkers.