Author

N. Irie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:chicken / avian· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. M. M. van Pelt· 1 shared A. Melcher· 1 shared B. J. Y. Tan· 1 shared B. Kalfaoglu· 1 shared C. Xu· 1 shared E. Appleton· 1 shared G. Hamer· 1 shared H. Hu· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. M. M. van Pelt

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4 papers

Recent·Most cited

Single-cell level temporal profiling of tumour-reactive T cells under immune checkpoint blockade

J. Hassan, E. Appleton, B. Kalfaoglu, M. Pedersen, J. Almeida-Santos, H. Kanemaru, N. Irie, S. Foo, O. Reda, B. J. Y. Tan, I.-m. Okazaki, T. Okazaki, Y. Satou, K. Harrington, A. Melcher, M. Ono

This study uses a novel mouse model to analyze how checkpoint blockade affects tumour-reactive T cell activation dynamics at the single-cell level.

bioRxiv · Jul 19, 2022 · PreprintImmunology

Tumors widely express hundreds of embryonic germline genes

J. W. Bruggeman, N. Irie, P. Lodder, A. M. M. van Pelt, J. Koster, G. Hamer

The paper identifies 672 germ cell cancer genes, expanding the known pool by 51%, and suggests they may offer better cancer treatment targets with fewer side effects.

bioRxiv · Sep 8, 2020Cancer Biology

Gene expression patterns in chordate embryonic development suggest partial applicability of Haeckel's postulates

P. Khaitovich, S. Guo, H. Hu, C. Xu, N. Irie

The paper examines mRNA expression patterns across nine species to assess the applicability of Haeckel's postulates, finding partial conservation and alignment with terminal edition patterns.

bioRxiv · Aug 25, 2020 · PreprintEvolutionary Biology

Evolutionary transition in accessible chromatin landscapes during vertebrate embryogenesis

M. Uesaka, S. Kuratani, H. Takeda, N. Irie

The paper shows that more evolutionarily derived gene regulatory regions are activated later in embryogenesis across three vertebrate species.

bioRxiv · Nov 29, 2018 · PreprintEvolutionary Biology