Author

G. Baele

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 5 Ecology· 2 Microbiology· 2 Immunology· 1

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Research Focus:host-pathogen & immune response· 5 Approach:statistical model· 5 Assay:whole-genome sequencing· 5 Approach:experimental assay· 4 Research Focus:phylogenetics / evolution· 4 Research Focus:benchmarking· 3 Organism:virus· 3 Approach:Bayesian inference· 2

Frequent Co-Authors

P. Lemey· 4 shared S. Dellicour· 4 shared N. De Maio· 3 shared P. Maes· 3 shared A. Rambaut· 2 shared B. Vanmechelen· 2 shared E. Andre· 2 shared S. L. Hong· 2 shared

Activity by Year

2019-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersEvolutionary Biology

P. Lemey

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10 papers

Recent·Most cited

Impact and mitigation of sampling bias to determine viral spread: evaluating discrete phylogeography through CTMC modeling and structured coalescent model approximations

M. Layan, N. F. Mueller, S. Dellicour, N. De Maio, H. Bourhy, S. Cauchemez, G. Baele

This study evaluates how sampling bias affects viral spread inference using phylogeographic models and proposes strategies to mitigate its impact through simulation and empirical datasets.

bioRxiv · Jul 7, 2022Evolutionary Biology

Delta-Omicron recombinant escapes therapeutic antibody neutralization

R. Duerr, H. Zhou, T. Tada, D. Dimartino, C. Marier, P. Zappile, G. Wang, J. Plitnick, S. Griesemer, R. C. Girardin, J. Machowski, S. Bialosuknia, E. Lasek-Nesselquist, S. L. Hong, G. Baele, , A. Heguy

This study identifies a Delta-Omicron recombinant SARS-CoV-2 variant that escapes Sotrovimab neutralization, highlighting the role of recombination in immune escape.

bioRxiv · Apr 6, 2022Microbiology

Considerable escape of SARS-CoV-2 variant Omicron to antibody neutralization

D. Planas, N. Saunders, P. Maes, F. G. Benhassine, C. Planchais, F. Porrot, I. Staropoli, F. Lemoine, H. Pere, D. Veyer, J. Puech, J. Rodary, W. H. Bolland, J. Buchrieser, G. Baele, , O. Schwartz

This study shows that the Omicron variant of SARS-CoV-2 is resistant to most monoclonal antibodies and vaccine-induced antibodies, with reduced neutralization compared to Delta.

bioRxiv · Dec 14, 2021Immunology

Updated vaccine protects from infection with SARS-CoV-2 variants, prevents transmission and is immunogenic against Omicron in hamsters

S. Sharma, T. Vercruysse, L. Sanchez-Felipe, W. Kerstens, P. Maes, R. Abdelnabi, C. S. Foo, V. Lemmens, D. Van Looveren, G. Baele, B. Weynand, P. Lemey, J. Neyts, H. J. Thibaut, K. Dallmeier

This study shows an updated vaccine candidate provides full protection against multiple SARS-CoV-2 variants, prevents transmission, and induces neutralizing antibodies against Omicron in hamsters.

bioRxiv · Nov 12, 2021 · PreprintMicrobiology

Accommodating individual travel history, global mobility, and unsampled diversity in phylogeography: a SARS-CoV-2 case study.

P. Lemey, S. Hong, V. Hill, G. Baele, C. Poletto, V. Colizza, A. O'Toole, J. T. McCrone, K. G. Andersen, M. Worobey, M. I. Nelson, A. Rambaut, M. A. Suchard

This paper integrates travel history data into Bayesian phylogeographic analysis of SARS-CoV-2 to improve virus spread reconstructions and address sampling bias.

bioRxiv · Jun 22, 2020 · PreprintEvolutionary Biology

A phylodynamic workflow to rapidly gain insights into the dispersal history and dynamics of SARS-CoV-2 lineages

S. Dellicour, K. Durkin, S. L. Hong, B. Vanmechelen, J. Marti-Carreras, M. S. Gill, C. Meex, S. Bontems, E. Andre, M. Gilbert, C. Walker, N. De Maio, N. R. Faria, J. Hadfield, M.-P. Hayette, , P. Maes

This paper introduces a phylodynamic workflow to analyze SARS-CoV-2 lineage dispersal, showing external introductions were key in Belgium and lockdowns had limited impact on transmission.

bioRxiv · May 5, 2020Evolutionary Biology

Temporal signal and the phylodynamic threshold of SARS-CoV-2

S. Duchene, L. Featherstone, M. Haritopoulou-Sinanidou, A. Rambaut, P. Lemey, G. Baele

This study assesses the phylodynamic threshold of SARS-CoV-2 by analyzing genome sequences over time to determine when reliable evolutionary rate and outbreak timing estimates became possible.

bioRxiv · May 4, 2020Evolutionary Biology

nosoi: a stochastic agent-based transmission chain simulation framework in R

S. Lequime, P. Bastide, S. Dellicour, P. Lemey, G. Baele

nosoi simulates transmission chains for infectious diseases using an agent-based framework, enabling validation of reconstruction methods and exploration of epidemic dynamics.

bioRxiv · Mar 3, 2020Ecology

Sampling bias and model choice in continuous phylogeography: getting lost on a random walk

A. Kalkauskas, U. Perron, Y. Sun, N. Goldman, G. Baele, S. Guindon, N. De Maio

The paper compares two phylogeographic models, showing that sampling bias affects Brownian Motion Phylogeography (BMP) and that the spatial Lambda-Fleming-Viot process (LambdaFV) is more robust but applicable to different scenarios.

bioRxiv · Feb 18, 2020Evolutionary Biology

Host relatedness and landscape connectivity shape pathogen spread in a large secretive carnivore

N. M. Fountain-Jones, S. Kraberger, R. Gagne, D. R. Trumbo, P. Salerno, W. C. Funk, K. Crooks, R. Biek, M. Alldredge, K. Logan, G. Baele, S. M. Dellicour, H. B. Ernest, S. VandeWoude, S. Carver, M. E. Craft

The paper examines how urbanization affects pathogen spread in pumas by analyzing landscape variables and host gene flow in two contrasting regions.

bioRxiv · Oct 23, 2019Ecology