T. Wai

Dynamic label-free analysis of SARS-CoV-2 infection reveals virus-induced subcellular remodeling.

This study uses AI and label-free microscopy to analyze subcellular changes in SARS-CoV-2 infected cells, revealing organelle remodeling and cross-regulation networks.

Mtfp1 ablation enhances mitochondrial respiration and protects against hepatic steatosis

This study shows that deleting Mtfp1 in hepatocytes increases mitochondrial respiration and protects against fatty liver disease.

Mitochondrial fission process 1 (MTFP1) controls bioenergetic efficiency and prevents inflammatory cardiomyopathy and heart failure in mice

This study shows that MTFP1 is critical for cardiac function, as its loss in mice leads to dilated cardiomyopathy, heart failure, and death due to mitochondrial dysfunction and increased cell death.

Distinct molecular signatures of fission predict mitochondrial degradation or proliferation

The paper identifies two distinct fission types in mitochondria, one leading to degradation and the other to proliferation, both Drp1-mediated but using different adaptors and pre-constriction mechanisms.

Enhanced cGAS-STING-dependent interferon signaling associated with mutations in ATAD3A

The paper identifies mutations in ATAD3A causing enhanced type I interferon signaling in patients with neurological and autoimmune features.

High-throughput phenotypic screen for genetic modifiers in patient-derived OPA1 mutant fibroblasts identifies PGS1 as a functional suppressor of mitochondrial fragmentation

This study identifies PGS1 as a genetic modifier that suppresses mitochondrial fragmentation in OPA1 mutant fibroblasts through lipid metabolism modulation.