N. Svetec

Comparative Single Cell Analysis of Transcriptional Bursting Reveals the Role of Genome Organization on de novo Transcript Origination

The paper identifies a core gene set for cross-species cell type classification in Drosophila and shows genome organization influences transcriptional bursting and de novo gene origination during spermatogenesis.

The Origin and Evolution of Sex Peptide and Sex Peptide Receptor Interactions

This study investigates the evolutionary origin of sex peptide (SP) and sex peptide receptor (SPR) interactions using ancestral sequence reconstruction, AlphaFold2, and molecular dynamics simulations.

The evolution and mutational robustness of chromatin accessibility in Drosophila

This study uses deep neural networks to analyze chromatin accessibility in Drosophila, showing sequence determinants are conserved and accessibility is mutationally robust yet malleable under selection.

The 3-Dimensional Genome Drives the Evolution of Asymmetric Gene Duplicates via Enhancer Capture-Divergence

This paper shows that enhancer capture-divergence (ECD) is a significant evolutionary mechanism for asymmetric, distally duplicated genes, using Drosophila HP6/Umbrea as an example.

Transcriptional and mutational signatures of the aging germline

This study investigates age-related changes in mutation rates and gene expression in Drosophila germline cells, finding distinct mutational biases and increased post-meiotic gene expression in older flies.

Intermolecular interactions drive protein adaptive and co-adaptive evolution at both species and population levels

The paper investigates how intermolecular interactions influence protein adaptation and co-adaptation across species and populations.

Transcription factors drive opposite relationships between gene age and tissue specificity in male and female Drosophila gonads

The paper shows that gene age and tissue specificity differ between male and female Drosophila gonads, with older genes being more ovary-biased and younger genes more testis-biased.

Behavioral and genomic sensory adaptations underlying the pest activity of Drosophila suzukii

This study investigates the evolutionary basis of Drosophila suzukii's egg-laying behavior by combining behavioral, genomic, and gene expression analyses with closely related species.

The evolution of sex-biased gene expression in the Drosophila brain

This study investigates the evolution of sex-biased gene expression in Drosophila brain tissues, finding enrichment on the X chromosome and evidence of directional selection and genetic constraints.

Testis single-cell RNA-seq reveals the dynamics of de novo gene transcription and germline mutational bias in Drosophila

This study uses single-cell RNA-seq to analyze de novo gene expression and mutational patterns in Drosophila testis across spermatogenesis.