Author

U. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Evolutionary Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:Drosophila· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

C. Li· 2 shared L. Zhao· 2 shared N. Svetec· 2 shared A. Guzzetta· 1 shared A. M. Fundichely· 1 shared A. Polyzos· 1 shared A. Rosowicz· 1 shared C. B. Langer· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersEvolutionary Biology

C. Li

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

TAD hierarchy restricts poised LTR activation and loss of TAD hierarchy promotes LTR co-option in cancer

E. W. P. Wong, M. Sahin, R. Yang, U. Lee, Y. A. Zhan, R. Misra, F. Tomas, N. Alomran, A. Polyzos, C. J. Lee, T. Trieu, A. M. Fundichely, T. Wiesner, A. Rosowicz, S. Cheng, , P. Chi

The paper shows that TAD hierarchy restricts LTR activation, and its loss in cancer allows LTRs to act as alternative promoters, driving oncogene activation and transcriptional diversity.

bioRxiv · May 31, 2024 · PreprintCancer Biology

Comparative Single Cell Analysis of Transcriptional Bursting Reveals the Role of Genome Organization on de novo Transcript Origination

U. Lee, C. Li, C. B. Langer, N. Svetec, L. Zhao

The paper identifies a core gene set for cross-species cell type classification in Drosophila and shows genome organization influences transcriptional bursting and de novo gene origination during spermatogenesis.

bioRxiv · Apr 29, 2024Evolutionary Biology

The 3-Dimensional Genome Drives the Evolution of Asymmetric Gene Duplicates via Enhancer Capture-Divergence

U. Lee, D. Arsala, S. Xia, C. Li, M. Ali, N. Svetec, C. Langer, D. Sobreira, I. Eres, D. Sosa, J. Chen, L. Zhang, P. Reilly, A. Guzzetta, J. J. Emerson, , M. Long

This paper shows that enhancer capture-divergence (ECD) is a significant evolutionary mechanism for asymmetric, distally duplicated genes, using Drosophila HP6/Umbrea as an example.

bioRxiv · Nov 30, 2022 · PreprintEvolutionary Biology