S. Xia

Positive Selection on Rare Variants Underlying the Cold Adaptation of Wild Boar

This study identifies rare variants under positive selection in wild boar linked to cold adaptation, showing convergent molecular evolution with humans.

Benchmarking organ-specific responses to therapies in tissues differentiated from Cystic Fibrosis patient derived iPSCs

This study benchmarks Trikafta's efficacy in CF patient-derived iPSC-derived colonic and airway tissues compared to isogenic controls, showing differential therapeutic responses.

One million years of solitude: the rapid evolution of de novo protein structure and complex

This study examines the rapid structural evolution of de novo genes in rice over 1 million years, finding faster changes in disordered regions and structured elements compared to gene duplicates.

Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection.

This study identifies evolutionarily new genes in humans with disease phenotypes, showing their enrichment in male reproductive diseases and adaptive traits like brain size and color vision.

Depleting glioblastoma cells of very long-chain acyl-CoA synthetase 3 (ACSVL3) produces metabolic alterations in non-lipid pathways

This study shows that knocking out ACSVL3 in glioblastoma cells reduces their malignant traits by altering non-lipid metabolic pathways, including glucose and energy metabolism.

VERY LONG-CHAIN ACYL-CoA SYNTHETASE-3 (ACSVL3) PROMOTES THE MALIGNANT GROWTH BEHAVIOR OF U87 GLIOMA CELLS VIA CHANGES IN CELL CYCLE WITHOUT AFFECTING APOPTOSIS

This study shows that reducing ACSVL3 expression in U87 glioma cells slows their growth and tumor formation in mice by altering the cell cycle without affecting apoptosis.

New gene evolution with subcellular expression patterns detected in PacBio-sequenced genomes of Drosophila genus

The paper analyzes gene age and subcellular expression patterns in Drosophila species using PacBio sequencing, finding new genes enriched in extracellular compartments and old genes in mitochondria and plasma membrane.

The 3-Dimensional Genome Drives the Evolution of Asymmetric Gene Duplicates via Enhancer Capture-Divergence

This paper shows that enhancer capture-divergence (ECD) is a significant evolutionary mechanism for asymmetric, distally duplicated genes, using Drosophila HP6/Umbrea as an example.

Highly synchronized cortical circuit dynamics mediate spontaneous pain

This study shows that spontaneous pain induces synchronized neural dynamics in the primary somatosensory cortex, and reversing this synchronization alleviates pain.

Global Spatial Transcriptome of Macaque Brain at Single-Cell Resolution

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

JQ-1 ameliorates schistosomiasis liver granuloma in mice by suppressing male and female reproductive systems and egg development of Schistosoma japonicum

This study shows JQ-1 reduces liver granuloma size and egg production in Schistosoma japonicum-infected mice by inhibiting reproductive system development and gene expression.

Rapid gene evolution in an ancient post-transcriptional and translationalregulatory system compensates for meiotic X chromosomal inactivation

This study shows that recently evolved genes in Drosophila compensate for meiotic X chromosomal inactivation by rapidly adapting in post-transcriptional and translational regulation.

Species-specific gene duplication in Arabidopsis thaliana evolved novel phenotypic effects on morphological traits under strong positive selection

This study identifies a young gene in Arabidopsis thaliana that shows strong positive selection and contributes to morphological trait divergence through neofunctionalization.

Generation of functional ciliates cholangiocytes from human pluripotent stem cells

This study generates functional cholangiocytes from human pluripotent stem cells that exhibit mature characteristics and can be used for drug testing and disease modeling.

Oviposition of the mosquito Aedes aegypti in forest and domestic habitats in Africa

This study examines oviposition behavior differences between forest and domestic Aedes aegypti in Africa, finding limited evidence of strong environmental-driven divergence in oviposition preferences.

Fully human single-domain antibodies against SARS-CoV-2

This paper develops fully human single-domain antibodies against SARS-CoV-2 and identifies their neutralizing activity and immunogenic profile compared to SARS-CoV and MERS-CoV.

Inhibition of SARS-CoV-2 infection (previously 2019-nCoV) by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

This paper identifies EK1C4, a potent fusion inhibitor against SARS-CoV-2 and other coronaviruses, showing high efficacy in vitro and in vivo.

Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody

This study shows that the SARS-CoV-specific antibody CR3022 binds strongly to 2019-nCoV RBD with a KD of 6.3 nM, while other antibodies targeting the ACE2 site fail to bind, highlighting the importance of RBD differences for cross-reactivity.

Molecular organization of integrin-based adhesion complexes in mouse Embryonic Stem Cells

This study investigates the molecular and structural organization of focal adhesions in mouse embryonic stem cells, revealing a compact nanoscale architecture and ECM-dependent regulation.

Identification of pyroptosis inhibitors that target a reactive cysteine in gasdermin D

This paper identifies disulfiram and Bay 11-7082 as pyroptosis inhibitors that covalently modify a conserved cysteine in gasdermin D, thereby blocking pore formation and inflammation.