R. Offringa

Employing RNA editing to engineer personalized tumor-specific neoantigens (editopes)

This paper develops a method to generate tumor-specific neoantigens using RNA editing, demonstrating its ability to create immunogenic epitopes that activate T cells and enhance immunotherapy potential.

optiPRM: A targeted immunopeptidomics LC-MS workflow with ultra-high sensitivity for the detection of mutation-derived tumor neoepitopes from limited input material

The paper introduces optiPRM, a targeted LC-MS workflow that enhances sensitivity for detecting mutation-derived neoepitopes from limited tumor samples.

Incorporation of TRDV segments into TCR alpha chains

The paper identifies TRDV segments incorporated into TCR alpha chains in human and murine tumor models and shows their prevalence in 10X VDJ datasets.

Key role of auxin cellular accumulation in totipotency and pluripotency acquisition

This study shows that using natural auxins with auxin transport inhibitor NPA improves plant regeneration efficiency in Arabidopsis and Brassica napus.

Structure-activity relationship of 2,4-D correlates auxin activity with the induction of somatic embryogenesis in Arabidopsis thaliana

This study investigates the structure-activity relationship of 2,4-D analogues in Arabidopsis thaliana, finding a strong correlation between auxin activity and somatic embryogenesis induction.

Deep molecular characterization linked to drug response profiling of pancreatic ductal adenocarcinoma using patient-derived organoids.

This study uses patient-derived PDAC organoids to integrate genomic, transcriptomic, and drug response data, identifying novel biomarkers and resistance mechanisms for personalized treatment.

Endogenous auxin directs development of embryonic stem cells into somatic proembryos in Arabidopsis

This study shows that auxin biosynthesis and polar transport are essential for somatic proembryo development and differentiation in Arabidopsis after embryonic competence is acquired.

A novel pathway controlling cambium initiation and -activity via cytokinin biosynthesis in Arabidopsis

This study identifies AHL15 as a key regulator of vascular cambium activity and secondary xylem formation in Arabidopsis through cytokinin biosynthesis.

miR156-independent repression of the ageing pathway bylongevity-promoting AHL proteins in Arabidopsis

This study shows AHL15 and its family members repress the SPL-driven ageing pathway in Arabidopsis, delaying vegetative phase change and flowering time independently of miR156/157.

An Arabidopsis AT-hook motif nuclear protein mediates somatic embryogenesis and coinciding genome duplication

This study shows AHL15 overexpression induces somatic embryogenesis in Arabidopsis without hormones and leads to polyploid plants through endomitosis during SE initiation.

A suppressor of axillary meristem maturation promotes longevity in flowering plants

This study identifies AHL15 as a suppressor of axillary meristem maturation that promotes plant longevity in Arabidopsis and tobacco by extending lifespan through delayed meristem maturation.

Phosphoproteomics of CD2 signaling reveals an AMPK-dependent regulation of lytic granule polarization in cytotoxic T cells

PDK1 has a pleiotropic PINOID-independent role in Arabidopsis development

This study shows that PDK1 has a role in Arabidopsis development independent of PINOID, affecting auxin transport and causing growth defects in pdk1 pdk2 mutants.