Author

O. Yang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Organism:yeast· 1

Frequent Co-Authors

T. Ha· 3 shared A. Poddar· 2 shared D. Singh· 2 shared J. Mallon· 2 shared S. Bailey· 2 shared Y. Wang· 2 shared C.-T. Lin· 1 shared D. Ceylan· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiophysics

T. Ha

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3 papers

Recent·Most cited

Rapid long-distance migration of RPA on single stranded DNA occurs through intersegmental transfer utilizing multivalent interactions

S. Pangeni, G. Biswas, V. Kaushik, S. Kuppa, O. Yang, C.-T. Lin, G. Mishra, Y. Levy, E. Antony, T. Ha

This study investigates RPA's long-distance migration on ssDNA using biophysical methods, finding that intersegmental transfer via multivalent interactions enables rapid diffusion under tension.

bioRxiv · Dec 9, 2023Biophysics

Real-time observation of DNA target interrogation and product release by the RNA-guided endonuclease CRISPR Cpf1

D. Singh, J. Mallon, A. Poddar, Y. Wang, R. Tipanna, O. Yang, S. Bailey, T. Ha

This study characterizes the DNA interrogation and product release kinetics of three Cpf1 orthologues using single-molecule fluorescence and biochemical assays, revealing differences from Cas9 in binding and cleavage requirements.

bioRxiv · Apr 9, 2018Biophysics

Mechanisms of improved specificity of engineered Cas9s revealed by single molecule analysis

D. Singh, Y. Wang, J. Mallon, O. Yang, J. Fei, A. Poddar, D. Ceylan, S. Bailey, T. Ha

This study reveals how engineered Cas9 variants improve specificity by altering DNA unwinding dynamics and cleavage rates in response to mismatches.

bioRxiv · Sep 22, 2017Biophysics