Author

C.-T. Lin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biophysics· 2 Cancer Biology· 1 Cell Biology· 1 Pharmacology & Toxicology· 1 Physiology· 1

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Approach:experimental assay· 5 Organism:human· 3 Organism:mouse· 3 Approach:deep learning· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

P. D. Neufer· 2 shared T. Ha· 2 shared A. R. Verkerke· 1 shared C. B. Coleman· 1 shared C. F. Burant· 1 shared C. Liu· 1 shared C. M. Karner· 1 shared C. Schmidt· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCell Biology

P. D. Neufer

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Author profile →

8 papers

Recent·Most cited

Rapid long-distance migration of RPA on single stranded DNA occurs through intersegmental transfer utilizing multivalent interactions

S. Pangeni, G. Biswas, V. Kaushik, S. Kuppa, O. Yang, C.-T. Lin, G. Mishra, Y. Levy, E. Antony, T. Ha

This study investigates RPA's long-distance migration on ssDNA using biophysical methods, finding that intersegmental transfer via multivalent interactions enables rapid diffusion under tension.

bioRxiv · Dec 9, 2023Biophysics

Massively parallel single molecule tracking of sequence-dependent DNA mismatch repair in vivo

T. Kayikcioglu, J. S. Zarb, S. Mohapatra, C.-T. Lin, J. A. London, K. D. Hansen, R. Fishel, T. Ha

The paper tracks DNA mismatch repair in E. coli using high-throughput sequencing and finds sequence-dependent repair efficiencies, with CC mismatches being poorly repaired and local context affecting TT, AG, and CT mismatches.

bioRxiv · Jan 8, 2023 · PreprintBiophysics

Graph Convolutional Learning of Multimodal Brain Connectome Data for Schizophrenia Classification

S. Ghosh, E. Bhargava, C.-T. Lin, S. S. Nagarajan

This paper applies graph convolutional neural networks to multimodal brain connectome data to classify schizophrenia, achieving an F1 score of 0.75.

bioRxiv · Jan 5, 2023 · PreprintBioengineering

Fragment Linker Prediction Using Deep Encoder-Decoder Network for PROTAC Drug Design

C.-T. Kao, C.-T. Lin, C.-L. Chao, C.-C. Lin

This paper introduces AIMLinker, a deep learning model that generates PROTACs analogs with improved chemical properties by integrating structural filters and molecular docking validation.

bioRxiv · Nov 17, 2022Pharmacology & Toxicology

Neuronal glucose metabolism sets cholinergic tone and controls thermo-regulated signaling at the neuromuscular junction

Y. Tang, H. Zong, H. Kwon, Y. Qiu, J. B. Pessin, L. Wu, K. A. Buddo, I. Boykov, C. Schmidt, C.-T. Lin, P. D. Neufer, G. J. Schwartz, I. J. Kurland, J. E. Pessin

This study shows that increasing glycolysis in cholinergic neurons boosts acetylcholine levels, reduces blood pressure and heart rate, and improves cold resistance.

eLife · Mar 7, 2022Peer-reviewedCell Biology

Human retrosplenial theta and alpha modulation in active spatial navigation

T.-T. Do, C.-T. Lin, K. Gramann

This study examines RSC neural dynamics during active spatial navigation, finding theta power increases during heading changes, suggesting head-direction computation in humans.

bioRxiv · Dec 1, 2020 · PreprintBioengineering

Epigenetic therapy remodels the immune synaptic cytoskeleton to potentiate cancer susceptibility to γδ T cells

R. R. Weng, H.-H. Lu, C.-T. Lin, C.-C. Fan, R.-S. Lin, T.-C. Huang, S.-Y. Lin, Y.-J. Huang, Y.-H. Juan, Y.-C. Wu, Z.-C. Hung, C. Liu, X.-H. Lin, W.-C. Hsieh, T.-Y. Chiu, , H.-C. Tsai

DNA methyltransferase inhibitors enhance γδ T cell-mediated lung cancer killing by remodeling immune synaptic cytoskeletal networks.

bioRxiv · Apr 30, 2020 · PreprintCancer Biology

Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity

T. D. Heden, J. M. Johnson, P. J. Ferrara, H. Eshima, A. R. Verkerke, E. J. Wentzler, P. Siripoksup, T. M. Narowski, C. B. Coleman, C.-T. Lin, T. E. Ryan, P. T. Reidy, L. E. de Castro Bras, C. M. Karner, C. F. Burant, , K. Funai

The paper shows that mitochondrial phospholipids, specifically phosphatidylethanolamine (PE), regulate respiratory capacity in skeletal muscle, with PE deficiency causing respiratory failure and oxidative stress.

bioRxiv · Apr 9, 2019Physiology