P. A. Coulombe

The paper identifies a keratin 17- and PKCα-dependent mechanism that transiently amplifies neutrophil influx in stressed skin, revealing a novel pathway in chronic inflammatory skin diseases.

This study shows that Keratin 17 regulates nuclear morphology, chromatin organization, and cell proliferation in epithelial cells.

This study shows that keratins K6 and K16 regulate mitochondrial structure, function, and dynamics in keratinocytes, contributing to oxidative stress in pachyonychia congenita.

This study shows that K14-dependent disulfides regulate epidermal homeostasis and barrier function through interactions with 14-3-3sigma and YAP1.

The paper determines the crystal structure of a keratin 5 and 14 2B domain complex and identifies key interactions critical for intermediate filament assembly.