Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis
T. Zhang, S. Li, A. Y. Tan, J. Na, Z. Chen, P. Damle, X. Chen, S. Choi, B. Mishra, D. Wang, S. R. Grossman, X. Jiang, Y. Li, Y.-T. Chen, J. Z. Xiang, N. Du
This study identifies CtBP2 as a mediator of Bcl-xL nuclear translocation, which promotes metastasis by enhancing H3K4me3 and TGFβ transcription.
bioRxiv · Apr 26, 2023Cancer Biology