J. Na

Association of Gene Variant Type and Location with Breast Cancer Risk in the General Population

This study evaluates breast cancer risks associated with pathogenic variant type and location in BRCA2 and other genes, finding differential risks based on variant position.

Artificial Intelligence-Enabled AlphaFold II Pipeline Guides Functional Fluorescence Labeling of Tubulin Across Species

The paper develops an AI-driven method to label tubulin isotypes in vivo across species, enabling precise visualization of microtubule dynamics and pathogenic variants without disrupting cellular processes.

Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis

This study identifies CtBP2 as a mediator of Bcl-xL nuclear translocation, which promotes metastasis by enhancing H3K4me3 and TGFβ transcription.

Ambient temperature crystal structure of Escherichia coli CyaY protein displays alternate conformation

The paper presents the first ambient temperature crystal structure of Escherichia coli CyaY, revealing an alternate conformation and highlighting temperature's impact on protein structure.

STING activation promotes autologous type I interferon-dependent development of type 1 regulatory T cells during malaria

This study shows STING activation promotes Tr1 cell development during malaria by enhancing IFNB gene transcription and modulates this pathway with ruxolitinib.

Potentiating the cross-reactive IFN-γ T cell and polyfunctional T cell responses by heterologous GX-19N DNA booster in mice primed with either a COVID-19 mRNA vaccine or inactivated vaccine

This study evaluates the effectiveness of a DNA booster vaccine in enhancing immune responses in mice previously vaccinated with either an mRNA or inactivated SARS-CoV-2 vaccine.

Autophagic state prospectively identifies facultative stem cells in the intestinal epithelium

The paper identifies autophagic state as a marker for facultative stem cells in the intestinal epithelium, independent of lineage or cell age.

Marked enhancement of neutralizing antibody and IFN-γ T-cell responses by GX-19N DNA booster in mice primed with inactivated vaccine

This study shows that a heterologous prime-boost regimen using inactivated SARS-CoV-2 vaccine and GX-19N DNA vaccine enhances neutralizing antibody and IFN-γ T-cell responses against SARS-CoV-2 and its variants in mice.

High levels of truncated RHAMM cooperate with dysfunctional p53 to accelerate theprogression of pancreatic cancer

An inducible CRISPR-ON system for controllable gene activation in human pluripotent stem cells

This paper develops an inducible CRISPR-ON system to controllably activate genes in human pluripotent stem cells, demonstrating its ability to regulate NANOG expression and enhance cell survival and integration with mouse blastocysts.