V. Weaver

Assessing Heterogeneity in the N-Telopeptides of Type I Collagen by Mass Spectrometry

The paper develops a method to identify N-terminal cross-linked peptides from collagen I in Achilles tendon using mass spectrometry, revealing differences in cross-links in bovine pulmonary hypertension.

The microenvironment dictates glycocalyx construction and immune surveillance

This study shows that the physical properties of the microenvironment influence glycocalyx composition and immune surveillance in vitro using physiologically relevant models.

Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer

This study shows that low lamin A levels in breast cancer cells increase nuclear deformability and metastatic capacity, with lower lamin A levels linked to poorer disease-free survival in human tumors.

Myeloid mechano-metabolic programming restricts anti-tumor immunity

This study shows that fibrotic tumor microenvironments impair anti-tumor immunity through myeloid cell-driven metabolic changes that hinder CD8+ T cell function.

Vitamin D and the ability to produce 1,25(OH)2D are critical for protection from viral infection of the lungs.

This study shows that vitamin D deficiency worsens lung inflammation during H1N1 and SARS-CoV-2 infections, while sufficient vitamin D reduces inflammation, though not viral replication.

Microenvironmental engineering improves the self-organization of patterned microvascular networks

This study shows that engineering the microenvironment with fibrillar matrices and removing a serum component improves the self-organization of patterned endothelial cells into perfusable microvascular networks.

RNAseq studies reveal distinct transcriptional response to vitamin A deficiency in small intestine versus colon, uncovering novel vitamin A-regulated genes

This study compares gene expression in the small intestine and colon of vitamin A deficient mice, identifying distinct transcriptional responses and novel VA-regulated genes.