Author

P. Jakob

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Cortes Cabrera· 1 shared A. H. Smits· 1 shared A. Topp· 1 shared A.-M. Michon· 1 shared B. Banfai· 1 shared C. Stucki· 1 shared C.-y. Chen· 1 shared D. Eberhard· 1 shared

Activity by Year

2017-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiophysics

A. Cortes Cabrera

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Author profile →

2 papers

Recent·Most cited

Biological Plasticity Rescues Target Activity in CRISPR Knockouts

A. H. Smits, F. Ziebell, G. Joberty, N. Zinn, W. F. Mueller, S. Clauder-Münster, D. Eberhard, M. Fälth Savitski, P. Grandi, P. Jakob, A.-M. Michon, H. Sun, K. Tessmer, T. Bürckstümmer, M. Bantscheff, , W. Huber

The paper quantifies residual protein expression in CRISPR-Cas9 knockouts using RNA-seq and SPS-MS3, identifying mechanisms of partial protein preservation and functional retention.

bioRxiv · Jul 26, 2019Bioengineering

HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication

A. Cortes Cabrera, E. Melo, D. Roth, A. Topp, F. Delobel, C. Stucki, C.-y. Chen, P. Jakob, B. Banfai, T. Dunkley, O. Schilling, S. Huber, R. Iacone, P. Petrone

This study elucidates the allosteric mechanism of HtrA1 activation through inter-monomer communication, showing its role in proteolytic activity and disease-related pathologies.

bioRxiv · Jul 14, 2017Biophysics