The first days in the life of naïve human B-lymphocytes infected with Epstein-Barr virus
D. Pich, P. Mrozek-Gorska, M. Bouvet, A. Sugimoto, E. Akidil, A. Grundhoff, S. Hamperl, P. Ling, W. Hammerschmidt
This study identifies EBNA2 as essential for early EBV infection of naive B-cells, showing it drives activation, proliferation, and prevents cell death, while other latent genes have minimal or no effect during the pre-latent phase.
bioRxiv · Jun 11, 2019Microbiology