P. S. McPherson

This study identifies DENND6A as a Rab34 GEF that couples with Arl8b to regulate lysosomal retrograde trafficking and autophagy.

This study identifies DENND2B as a Rab35 GEF that regulates cytokinetic abscission and prevents tetraploidy by modulating actin dynamics and the NoCut checkpoint.

The paper evaluates 11 commercial antibodies for TBK1 detection in immunoblot, immunofluorescence, and immunoprecipitation using a knock-out cell line to identify potent and selective antibodies.

This study shows alpha-synuclein fibrils are rapidly internalized via macropinocytosis and directed to lysosomes, with some transferred to neighboring cells.

The paper shows that inhibiting the kinase CSNK2 blocks replication of several beta-coronaviruses, including SARS-CoV-2, by preventing viral entry.

This study shows that ITCH is required for clathrin-mediated endocytosis of EGFR and regulates its trafficking and signaling.

This study shows that loss of Rab35 or Arf5 in glioblastoma cells increases tumor growth and invasiveness by activating the epidermal growth factor receptor and upregulating SPOCD1.

This study shows SARS-CoV-2 enters cells via clathrin-mediated endocytosis, and inhibiting clathrin reduces viral infectivity.