Author

D. C. Wedge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 6

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 5 Research Focus:differential expression· 4 Research Focus:clustering· 3 Assay:whole-genome sequencing· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

A. Lambert· 2 shared A. Y. Warren· 2 shared C. Verrill· 2 shared D. J. Woodcock· 2 shared D. Leongamornlert· 2 shared F. C. Hamdy· 2 shared I. Martincorena· 2 shared M. Gerstung· 2 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCancer Biology

A. Lambert

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Author profile →

6 papers

Recent·Most cited

Novel Methylation Markers in a Prostate Cancer Cohort are Associated with Disease Development and Relapse

R. P. Lach, S. Pita, W.-K. Leung, A. Babbage, S. Merson, S. Hawkins, H. Luxton, J. Kay, H. C. Whitaker, D. J. Woodcock, V. Haberland, Z. Kote-Jarai, T. Milne-Clark, K. O'Neill, T. Brendler-Spaeth, , A. G. Lynch

The paper identifies novel methylation markers in a prostate cancer cohort associated with disease development and relapse, showing their predictive power for recurrence.

bioRxiv · Aug 27, 2026 · PreprintCancer Biology

Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of DYRK1A

C. K. Brierley, B. H. Yip, G. Orlando, H. Goyal, S. Wen, J. Wen, M. F. Levine, M. G. Jakobsdottir, A. Rodriguez-Meira, A. Adamo, M. Bashton, A. Hamblin, S. A. Clark, J. O'Sullivan, L. Murphi, , A. J. Mead

The paper identifies chromothripsis-induced amplification of DYRK1A in blast phase MPN as a driver of aggressive disease and a potential therapeutic target.

bioRxiv · Dec 8, 2023 · PreprintCancer Biology

Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole genome sequencing with histopathological features

S. R. Rao, C. Verrill, L. Cerundolo, N. K. Alham, Z. Kaya, M. O'Hanlon, A. Hayes, A. Lambert, M. James, I. D. C. Tullis, J. Niederer, S. Lovell, A. Omer, F. Lopez, T. Leslie, , F. C. Hamdy

This study integrates multi-region whole genome sequencing with histopathological data to reconstruct tumour phylogenies and identify molecular steps in prostate cancer progression and metastasis.

bioRxiv · Feb 27, 2023Cancer Biology

Clonal diversification and histogenesis of malignant germ cell tumours

T. R. W. Oliver, L. Chappell, R. Sanghvi, L. Deighton, N. Ansari-Pour, S. Dentro, M. D. Young, T. H. H. Coorens, H. Jung, T. M. Butler, M. D. C. Neville, D. Leongamornlert, M. A. Sanders, Y. Hooks, A. Cagan, , S. Behjati

This study analyzes the genome and transcriptome of 547 GCT histological units to explore clonal diversification and histogenesis, finding unifying genomic and transcriptional features across GCTs.

bioRxiv · Feb 1, 2022Cancer Biology

Genomic landscape and chronological reconstruction of driver events in multiple myeloma

F. Maura, N. Bolli, N. Angelopoulos, K. J. Dawson, D. Leongamornlert, I. Martincorena, T. J. Mitchell, A. Fullam, S. Gonzalez, R. Szalat, B. Rodriguez-Martin, M. K. Samur, D. Glodzik, M. Roncador, M. Fulciniti, , P. J. Campbell

This study reconstructs the genomic evolution of multiple myeloma by analyzing 67 genomes from 30 patients and public datasets, identifying 7 subgroups defined by distinct driver mutations and chronological patterns of genomic events.

bioRxiv · Aug 12, 2018Cancer Biology

Neutral tumor evolution?

M. Tarabichi, I. Martincorena, M. Gerstung, A. M. Leroi, F. Markowetz, P. T. Spellman, Q. D. Morris, O. C. Lingjaerde, D. C. Wedge, P. Van Loo, PCAWG Evolution and Heterogeneity Working Group

The paper explores tumor evolution through subclonal analysis and discusses the role of driver and passenger mutations in cancer progression.

bioRxiv · Jul 23, 2018Cancer Biology