Author

T. Madan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:proteomics· 4 Approach:experimental assay· 3 Approach:statistical model· 1

Frequent Co-Authors

U. Kishore· 4 shared N. Beirag· 3 shared S. Idicula-Thomas· 3 shared C. Kumar· 2 shared M. Mayora Neto· 2 shared N. J. Temperton· 2 shared P. M. Varghese· 2 shared V. Murugaiah· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersImmunology

U. Kishore

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4 papers

Recent·Most cited

Human complement Factor H and Properdin act as soluble pattern recognition receptors and differentially modulate SARS-CoV-2 Infection

N. Beirag, P. M. Varghese, C. Kumar, S. Idicula-Thomas, M. Mayora Neto, H. A. Khan, R. B. Sim, T. Madan, N. J. Temperton, U. Kishore

This study shows that complement factors FH and FP interact with SARS-CoV-2 proteins and differentially modulate viral entry and inflammatory responses in A549 cells.

bioRxiv · Jul 7, 2023 · PreprintImmunology

Human Surfactant Protein D Facilitates SARS-CoV-2 Pseudotype Binding and Entry in DC-SIGN Expressing Cells, and Downregulates Spike protein Induced Inflammation

N. Beirag, C. Kumar, T. Madan, M. H. Shamji, R. Bulla, D. Mitchell, V. Murugaiah, M. Mayora Neto, N. J. Temperton, S. Idicula-Thomas, P. M. Varghese, U. Kishore

This study shows that rfhSP-D enhances SARS-CoV-2 Spike protein binding to DC-SIGN and increases viral uptake in DC-SIGN-expressing cells while reducing inflammation.

bioRxiv · May 16, 2022Immunology

A recombinant fragment of Human surfactant protein D binds Spike protein and inhibits infectivity and replication of SARS-CoV-2 in clinical samples

T. Madan, B. Biswas, P. Varghese, R. Subedi, H. Pandit, S. Idicula-Thomas, I. Kundu, S. B. Rooge, R. Aggarwal, D. Tripathi, S. Kaur, E. Gupta, S. Gupta, U. Kishore

This study shows that a recombinant fragment of human SP-D inhibits SARS-CoV-2 spike protein binding to ACE-2 and reduces viral replication in clinical samples.

bioRxiv · Dec 18, 2020Immunology

Human Surfactant Protein D Binds S1 and Receptor Binding Domain of Spike protein and acts as an entry inhibitor of SARS-CoV-2 Pseudotyped viral particles in vitro

M.-H. Hsieh, N. Beirag, V. Murugaiah, Y.-C. Chou, W.-S. Kuo, H.-F. Kao, T. Madan, U. Kishore, J.-Y. Wang

This study shows that rfhSP-D binds SARS-CoV-2 S1 protein and inhibits viral entry into cells, suggesting its potential as an antiviral therapy.

bioRxiv · Dec 18, 2020Microbiology