Author

S. Roth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Bioengineering· 2 Ecology· 2 Evolutionary Biology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:cell type annotation· 5 Research Focus:differential expression· 5 Research Focus:host-pathogen & immune response· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

A. Liesz· 3 shared D. Brough· 2 shared J. Cao· 2 shared J. P. Green· 2 shared J. Zhu· 2 shared X. Li· 2 shared Y.-T. Chen· 2 shared A. Ali· 1 shared

Activity by Year

2018-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersImmunology

A. Liesz

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Neutrophil-derived complement factor P induces cytotoxicity in basal-like cells via caspase 3/7 activation in pancreatic cancer

U. Kishore, P. Varghese, A. Mangogna, L. Klein, M. Tu, L. Urbach, M. Qiu, R. Nicolle, V. Murugaiah, N. Beirag, S. Roth, D. Pedersen, R. Sim, V. Ellenrieder, G. R. Andersen, , S. Singh

This study shows that neutrophil-derived complement factor P induces apoptosis in basal-like pancreatic cancer cells via caspase 3/7 activation, linking properdin expression to better prognosis.

bioRxiv · Oct 28, 2023 · PreprintImmunology

Beneficial effects of intermittent fasting in NASH and subsequent HCC development are executed by concerted PPAR alpha and PCK1 action in hepatocytes

S. Gallage, A. Ali, J. E. Barragan Avila, N. Seymen, P. Ramadori, V. Joerke, L. Zizmare, J. Kosla, X. Li, E. Focaccia, S. Yousuf, T. Sijmonsma, M. Rahbari, K. S. Kommoss, A. Billeter, , M. Heikenwalder

This study shows intermittent fasting prevents NASH and HCC by PPAR alpha and PCK1 working together in liver cells.

bioRxiv · Oct 23, 2023 · PreprintCancer Biology

Single-cell precision nanotechnology in vivo

M. MOLBAY, B. Kick, S. Zhao, M. I. Todorov, T.-L. Ohn, S. Roth, A. Simats, V. Singh, I. Khalin, C. Pan, H. Singh Bhatia, F. Hellal, R. Zeidler, A. Liesz, N. Plesnila, , A. Erturk

This study demonstrates DNA origami can be directed in vivo to target immune cells and cancer metastases, showing potential for precision drug delivery.

bioRxiv · Jul 24, 2023 · PreprintBioengineering

Improving the sensitivity of fluorescence-based immunoassays by time-resolved and spatial-resolved measurements

R. Kremer, S. Roth, A. Bross, A. Danielli, Y. Noam

The paper improves the sensitivity of fluorescence-based immunoassays by combining time-resolved and spatial-resolved measurements in magnetic modulation biosensing.

bioRxiv · Mar 10, 2023 · PreprintBioengineering

Stroke induces early recurrent vascular events by inflammasome-dependent atherosclerotic plaque rupture

J. Cao, S. Roth, S. Zhang, A. Kopczak, M. K. Georgakis, X. Li, A. Dutsch, T. G. Liman, M. Endres, D. Brough, J. P. Green, S. R. Wernsdorf, C. Fürle, O. Carofiglio, J. Zhu, , A. Liesz

This study shows stroke triggers inflammasome-dependent atherosclerotic plaque rupture, leading to recurrent stroke, and identifies DNA-mediated inflammasome activation as a therapeutic target.

bioRxiv · Feb 1, 2023 · PreprintImmunology

Discovery of an AIM2 inflammasome inhibitor for the treatment of DNA-driven inflammatory disease.

J. P. Green, L. Y. El-Sharkawy, S. Roth, J. Zhu, J. Cao, A. Leach, A. Liesz, S. Freeman, D. Brough

The paper identifies inhibitors of DNA sensors like AIM2, cGAS, and TLR9, including 4-sulfonic calixarenes and suramin, showing potential for treating DNA-driven inflammatory diseases.

bioRxiv · Jul 28, 2022Immunology

Reduced parasite burden in feral honeybee colonies

P. L. Kohl, P. D'Alvise, B. Rutschmann, S. Roth, F. Remter, I. Steffan-Dewenter, M. Hasselmann

This study compares parasite burden between managed and feral honeybee colonies, finding lower parasite levels in feral colonies due to natural dispersal mechanisms.

bioRxiv · Jul 18, 2022Ecology

Immune function of the serosa in hemimetabolous insect eggs

C. G. Jacobs, R. van der Hulst, Y.-T. Chen, R. P. Williamson, S. Roth, M. van der Zee

The paper investigates immune function in the serosa of hemimetabolous insect eggs, finding immune competence is ancestral to all insects.

bioRxiv · Sep 27, 2021Evolutionary Biology

Striking parallels between dorsoventral patterning in Drosophila and Gryllus reveal a complex evolutionary history behind a model gene regulatory network

M. Pechmann, N. J. Kenny, L. Pott, P. Heger, Y.-T. Chen, T. Buchta, O. Ozuak, J. A. Lynch, S. Roth

The paper compares dorsoventral patterning in Drosophila and Gryllus, finding similarities in Toll signaling roles and suggesting convergent evolution or an ancient insect regulatory network.

bioRxiv · Oct 28, 2020Evolutionary Biology

Reconstitution of basic mitotic spindles in cell-like confinement

S. Roth, I. C. Garlea, M. Vleugel, B. Mulder, M. Dogterom

This study reconstitutes basic mitotic spindles in cell-like confinement using emulsion droplets, revealing mechanisms of spindle organization and force balance.

bioRxiv · Sep 16, 2019 · PreprintCell Biology

A molecular phylogeny of bedbugs elucidates the evolution of host associations and sex-reversal of reproductive trait diversification

S. Roth, O. Balvin, O. Di Iorio, M. T. Siva-Jothy, B. Petr, O. Calva, E. I. Faundez, M. McFadzen, M. P. Lehnert, F. A. A. Khan, R. Naylor, N. Simov, E. Morrow, E. Willassen, K. Reinhardt

This paper constructs a molecular phylogeny of bedbugs to trace the evolution of host associations and sex-reversal in reproductive traits.

bioRxiv · Jul 11, 2018 · PreprintEcology