A germline-targeting chimpanzee SIV envelope glycoprotein elicits a new class of V2-apex directed cross-neutralizing antibodies
F. Bibollet-Ruche, R. M. Russell, W. Ding, W. Liu, Y. Li, K. Wagh, D. Wrapp, R. Habib, A. N. Skelly, R. S. Roark, S. Sherrill-Mix, S. Wang, J. Rando, E. Lindemuth, K. Cruickshank, , B. H. Hahn
This study identifies a new class of V2-directed cross-neutralizing antibodies targeting a cryptic epitope in occluded-open HIV and SIV Env trimers.
bioRxiv · Oct 18, 2022Immunology