K. Wagh

Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies

This study uses molecular dynamics simulations to design HIV-1 immunogens that select for specific mutations in broadly neutralizing antibodies.

Germline-targeting chimpanzee SIV Envelopes induce V2-apex broadly neutralizing-like B cell precursors in a rhesus macaque infection model

This study shows that germline-targeting SCIVs can activate and expand B cells expressing V2-apex bnAb-like precursors in rhesus macaques.

Neutralization Escape by SARS-CoV-2 Omicron Subvariant BA.2.86

This study evaluates the neutralization escape of the SARS-CoV-2 Omicron subvariant BA.2.86 compared to other variants, finding lower neutralization by antibodies than BA.2 but comparable to circulating variants.

Mutational basis of serum cross-neutralization profiles elicited by infection or vaccination with SARS-CoV-2 variants

The paper models cross-neutralization profiles of SARS-CoV-2 sera against variants by analyzing mutations and shows that a third dose of mRNA-1273 improves neutralization breadth.

A germline-targeting chimpanzee SIV envelope glycoprotein elicits a new class of V2-apex directed cross-neutralizing antibodies

This study identifies a new class of V2-directed cross-neutralizing antibodies targeting a cryptic epitope in occluded-open HIV and SIV Env trimers.

Structural basis for breadth development in a HIV-1 neutralizing antibody

This paper determines structures of HIV-1 antibodies at different stages of maturation to understand how neutralization breadth develops through affinity optimization.

Single-molecule tracking reveals two low-mobility states for chromatin and transcriptional regulators within the nucleus

This study uses single-molecule tracking and machine learning to identify two low-mobility states of chromatin and transcriptional regulators, showing dynamic interactions and switching between states.

Engineering well-expressed, V2-immunofocusing HIV-1 envelope glycoprotein membrane trimers for use in heterologous prime-boost vaccine regimens

This paper engineers HIV-1 envelope trimers with enhanced V2 and fusion peptide neutralization sensitivity for vaccine development.

A tug of war between filament treadmilling and myosin induced contractility generates actin rings

The paper uses simulations and experiments to show that actin ring formation in cells depends on the balance between filament treadmilling and myosin contractility.

SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral Spike vaccines

This study shows that B.1.1.7 SARS-CoV-2 variant remains neutralizable by antibodies from ancestral Spike vaccines and convalescent sera, though with reduced efficacy.

Recapitulation of HIV-1 Env-Antibody Coevolution in Macaques Leading to Neutralization Breadth

Virus-antibody coevolution in rhesus macaques recapitulates developmental features of human antibodies.