Author

R. Farese

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 2 Physiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:metabolism & bioenergetics· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1

Frequent Co-Authors

T. C. Walther· 4 shared C. Chitraju· 2 shared Z. W. Lai· 2 shared A. Fischer· 1 shared A. Ibrahim· 1 shared A. W. Fischer· 1 shared B. Yuan· 1 shared C. Li· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersPhysiology

T. C. Walther

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Fitm2 is required for ER homeostasis and normal function of murine liver

L. M. Bond, A. Ibrahim, Z. W. Lai, R. L. Walzem, R. Bronson, O. Ilkayeva, T. C. Walther, R. Farese

This study shows that Fitm2 is essential for ER homeostasis and liver function in mice, with loss of Fitm2 causing ER stress and liver injury.

bioRxiv · May 24, 2022Cell Biology

Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity

C. Chitraju, A. W. Fischer, Y. A. Ambaw, K. Wang, B. Yuan, S. T. Hui, T. C. Walther, R. Farese

This study shows that mice lacking TG synthesis enzymes in adipose tissue are metabolically healthy and resistant to diet-induced obesity despite reduced TG storage.

bioRxiv · May 5, 2022 · PreprintPhysiology

Key Factors Governing Initial Stages of Lipid Droplet Formation

S. Kim, C. Li, R. Farese, T. C. Walther, G. A. Voth

This study uses a coarse-grained model to investigate the biophysics of lipid droplet formation, showing that membrane rigidity and asymmetric tension influence TG nucleation and budding direction.

bioRxiv · Nov 12, 2021Biophysics

Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis

C. Chitraju, A. Fischer, R. Farese, T. C. Walther

This study shows that lipid droplets in brown adipose tissue are not required for cold-induced thermogenesis, as mice lacking triglyceride synthesis enzymes maintain thermogenic function through alternative fuel sources.

bioRxiv · Mar 30, 2020Physiology

Cryo-electron microscopy structure of the lipid droplet-formation protein seipin

X. Sui, H. Arlt, K. Brook, Z. W. Lai, F. DiMaio, D. Marks, M. Liao, R. Farese, T. Walther

The paper reports the cryo-EM structure of D. melanogaster seipin and proposes a model for its role in lipid droplet formation.

bioRxiv · Sep 14, 2018Cell Biology