R. H. Ebright

This paper identifies the structural basis of σ-dependent transcriptional pausing by showing that it involves backtracked or scrunched states of RNA polymerase, depending on the presence of GreB.

The paper identifies promoter sequence determinants and structural basis of primer-dependent transcription initiation in E. coli using MASTER and biochemical studies.

This study reveals the mechanism of promoter unwinding during transcription initiation in bacteria using single-molecule techniques, identifying a 'bind-unwind-load-and-lock' process.

The paper investigates metabolomic profiles of Streptomyces sp. ID38640 and its mutants, identifying new metabolites and biosynthetic pathways.

XACT-seq identifies promoter-position and sequence determinants for initial-transcription pausing in Escherichia coli by measuring RNAP-active-center position relative to DNA with single-nucleotide resolution.

This paper reports crystal structures showing the stepwise displacement of the σ finger in bacterial transcription initiation factors driven by RNA extension during initial transcription.

The paper shows mitochondrial RNA polymerases in yeast and human cells efficiently cap RNA with NAD+ and NADH, linking metabolism to mitochondrial gene expression.

The paper introduces CapZyme-Seq to detect NCIN-capped RNA and identifies a consensus promoter sequence for NAD+ capping in E. coli.