Author

U. Basu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:yeast· 4 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 2 Assay:structural biology· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

S. S. Patel· 4 shared J. Shen· 3 shared G. Rothschild· 2 shared A. B. Heimberger· 1 shared A. Deshpande· 1 shared A. M. Sonabend· 1 shared A. Mahajan· 1 shared A. Mela· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersBiochemistry

S. S. Patel

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Author profile →

6 papers

Recent·Most cited

Yeast mtDNA transcription initiation in single nucleotide addition steps

Q. Goovaerts, J. Shen, B. De Wijngaert, U. Basu, S. S. Patel, K. Das

This study reports cryo-EM structures of yeast mitochondrial RNA polymerase initiation complexes, revealing the stepwise process of transcription initiation and the role of structural changes in RNA synthesis.

bioRxiv · Sep 27, 2022 · PreprintBiochemistry

A ChIP-exo screen of 887 PCRP transcription factor antibodies in human cells

W. K. Lai, L. Mariani, G. Rothschild, E. R. Smith, B. J. Venters, T. R. Blanda, P. K. Kuntala, K. Bocklund, J. Mairose, S. N. Dweikat, K. Mistretta, M. J. Rossi, D. James, J. T. Anderson, S. K. Phanor, , B. F. Pugh

The paper evaluates 887 PCRP antibodies against human transcription factors using ChIP-exo and other assays, identifying 5% as strong candidates and 34% as warranting further testing.

bioRxiv · Jun 8, 2020Biochemistry

Auto-inhibitory regulation of DNA binding by the C-terminal tails of the mitochondrial transcription factors Mtf1 and TFB2M

U. Basu, N. Mishra, M. Farooqui, J. Shen, L. C. Johnson, S. S. Patel

This study identifies autoinhibitory mechanisms in Mtf1 and TFB2M where the C-tail region regulates DNA binding activity through intramolecular interactions, which are relieved by RNA polymerase interaction.

bioRxiv · Mar 6, 2020Biochemistry

The Dynamic Landscape of Transcription Initiation in Yeast Mitochondria

B.-K. Sohn, U. Basu, S.-W. Lee, H. Cho, J. Shen, A. Deshpande, S. S. Patel, H. Kim

This study investigates the conformational dynamics of yeast mitochondrial transcription initiation using single-molecule techniques, revealing dynamic transitions and backtracking behavior.

bioRxiv · Dec 16, 2019Biophysics

CD8+ T-cell-mediated immunoediting influences genomic evolution and immune evasion in murine gliomas

J. R. Kane, J. Zhao, T. Tsujiuchi, B. Laffleur, A. Mahajan, G. Rao, A. Mela, C. Dmello, V. A. Arrieta, L. Chen, D. Y. Zhang, E. Gonzalez-Buendia, C. Lee-Chang, T. Xiao, G. Rothschild, , A. M. Sonabend

This study shows that CD8+ T-cells mediate immunoediting in murine gliomas, affecting genomic stability and immune evasion.

bioRxiv · Jul 16, 2019Cancer Biology

Mitochondrial RNA capping: highly efficient 5’-RNA capping with NAD+ and NADH by yeast and human mitochondrial RNA polymerase

J. G. Bird, U. Basu, D. Kuster, A. Ramachandran, E. Grudzien-Nogalska, M. Kiledjian, D. Temiakov, S. S. Patel, R. H. Ebright, B. E. Nickels

The paper shows mitochondrial RNA polymerases in yeast and human cells efficiently cap RNA with NAD+ and NADH, linking metabolism to mitochondrial gene expression.

bioRxiv · Oct 1, 2018Biochemistry