R. Lopez

Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation

The paper identifies SNC80 as a drug that reversibly slows metabolism in Xenopus and demonstrates its cross-species applicability in human organs-on-chips and porcine organs.

Inherent Metabolic Adaptations in Adult Spiny Mouse (Acomys) Cardiomyocytes Facilitate Enhanced Cardiac Recovery Following Myocardial Infarction

This study identifies unique metabolic adaptations in Acomys cardiomyocytes that enhance cardiac recovery after myocardial infarction compared to Mus musculus.

Unveiling the antiviral capabilities of targeting Human Dihydroorotate Dehydrogenase against SARS-CoV-2

This study identifies quinone-based compounds that inhibit HsDHODH and show anti-SARS-CoV-2 activity with low toxicity and nanomolar IC50.

Phenotypic and omics analyses of the Sordariomycetes Marquandomyces marquandii and Albophoma yamanashiensis isolated from estuarine sediments.

The paper isolates and characterizes two marine filamentous fungi, analyzing their secondary metabolite production and enzymatic responses to algal polysaccharides.

Reconstructing unobserved cellular states from paired single-cell lineage tracing and transcriptomics data

The paper introduces TreeVAE, a probabilistic framework to reconstruct unobserved ancestral cellular states from single-cell lineage tracing and transcriptomics data, showing improved performance over benchmarks.

Massively Multiplexed Affinity Characterization of Therapeutic Antibodies Against SARS-CoV-2 Variants

The paper measures binding affinities of 33 therapeutic antibodies against SARS-CoV-2 variants to identify epitopes and predict future efficacy against RBD mutations.

Deep Generative Models for Detecting Differential Expression in Single Cells

This paper introduces deep generative models for differential expression detection in scRNA-seq, showing improved performance over existing methods.

Scaling up DNA data storage and randomaccess retrieval

This paper demonstrates large-scale DNA data storage with random access, storing 200MB of data in 13 million DNA oligonucleotides and achieving error-free retrieval.