E. Gardner

Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation

The paper identifies SNC80 as a drug that reversibly slows metabolism in Xenopus and demonstrates its cross-species applicability in human organs-on-chips and porcine organs.

SMCHD1 activates the expression of genes required for the expansion of human myoblasts

This study shows SMCHD1 activates cell cycle genes in human myoblasts, promoting proliferation independently of DUX4, and identifies LAP2 as a key target gene.

LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase

This study identifies LKB1's role in suppressing growth by activating PIKFYVE to promote EGFR internalization in LUAD.

Target-agnostic discovery of Rett Syndrome therapeutics by coupling computational network analysis and CRISPR-enabled in vivo disease modeling

This paper identifies vorinostat as a potential repurposed therapy for Rett syndrome by combining computational network analysis with CRISPR-edited Xenopus models, showing efficacy across multiple organ systems.

Pursuing the Mechanisms Underlying Alcohol-Induced Changes in the Ghrelin System: New Insights from Preclinical and Clinical Investigations

This study investigates how alcohol affects the ghrelin system in humans and rats, finding that ethanol reduces peripheral ghrelin levels without involving the ghrelin receptor or GOAT enzyme, and not proportionally to caloric intake.

Long-distance dispersal shaped the diversity of tribe Dorstenieae (Moraceae)

This study investigates the biogeographic history of tribe Dorstenieae, finding that long-distance dispersal across the Atlantic shaped its Neotropical diversity.