R. Pepperkok

Reflection confocal microscopy for quantitative assessment of airway surface liquid dysregulation and pharmacological rescue in cystic fibrosis under near-physiological conditions

This paper introduces confocal reflection microscopy as a method to measure airway surface liquid height in cystic fibrosis models without perturbing the ASL, showing it is sensitive to detect ASL changes and therapeutic responses.

Dextromethorphan inhibits collagen transport in the endoplasmic reticulum eliciting an anti-fibrotic response in ex-vivo and in vitro models of pulmonary fibrosis

This study shows Dextromethorphan reduces collagen deposition in fibrotic models by inhibiting collagen trafficking in the endoplasmic reticulum.

Spatiotemporal dynamics of DNA repair proteins between the Golgi and nucleus maintain genomic stability.

The paper identifies dynamic redistribution of DNA repair proteins between the Golgi and nucleus in response to DNA damage, revealing a spatiotemporal coordination role for the Golgi in maintaining genomic stability.

Quantitative imaging reveals PI3Kδ inhibition reduces rhinovirus-induced damage of small airway epithelia in ex vivo cultured human precision cut lung slices from COPD patients

CLEMSite, a software for automated phenotypic screens using light microscopy and FIB-SEM

The paper introduces CLEMSite, a software tool for automated phenotypic screens using light microscopy and FIB-SEM, enabling high-throughput volume acquisition with reduced operator supervision.

A high throughput SEC23 functional interaction screen reveals a role for focal adhesion and extracellular matrix signalling in the regulation of COPII subunit SEC23A

The paper screens 378 cytoskeleton-associated proteins for functional interactions with COPII subunits SEC23A and SEC23B, identifying regulators linked to focal adhesion and ECM signaling.

Global distribution patterns of marine nitrogen-fixers by imaging and molecular methods

The paper combines imaging and molecular data to analyze the global distribution of marine nitrogen-fixers, revealing size-related patterns and new high-density regions.

Multiomic and quantitative label-free microscopy-based analysis of ex vivo culture and TGFbeta1 stimulation of human precision-cut lung slices

The paper uses multiomic and microscopy techniques to study fibrosis in human lung slices, showing increased collagen deposition with TGFbeta1 stimulation and a novel SHG-based method to quantify it.