A. Halavatyi

Dextromethorphan inhibits collagen transport in the endoplasmic reticulum eliciting an anti-fibrotic response in ex-vivo and in vitro models of pulmonary fibrosis

This study shows Dextromethorphan reduces collagen deposition in fibrotic models by inhibiting collagen trafficking in the endoplasmic reticulum.

Targeted volume Correlative Light and Electron Microscopy of an environmental marine microorganism

The paper demonstrates a method to target and analyze the 3D ultrastructure of a photosynthetic marine microorganism using correlative light and electron microscopy.

Quantitative imaging reveals PI3Kδ inhibition reduces rhinovirus-induced damage of small airway epithelia in ex vivo cultured human precision cut lung slices from COPD patients

A high throughput SEC23 functional interaction screen reveals a role for focal adhesion and extracellular matrix signalling in the regulation of COPII subunit SEC23A

The paper screens 378 cytoskeleton-associated proteins for functional interactions with COPII subunits SEC23A and SEC23B, identifying regulators linked to focal adhesion and ECM signaling.

Nuclear pores constrict upon energy depletion

This study shows that nuclear pore complexes constrict when cells experience energy depletion, linking cellular energy status to NPC conformation.

Dense encoding of developmental regulatory information may constrain evolvability

The paper investigates the evolutionary potential of regulatory changes in developmental enhancers by analyzing mutations in Drosophila melanogaster, finding that most mutations affect gene expression and suggest dense regulatory information that may constrain evolvability.

Multiomic and quantitative label-free microscopy-based analysis of ex vivo culture and TGFbeta1 stimulation of human precision-cut lung slices

The paper uses multiomic and microscopy techniques to study fibrosis in human lung slices, showing increased collagen deposition with TGFbeta1 stimulation and a novel SHG-based method to quantify it.