This paper describes a method to engineer large focal amplifications in primary cells using ecDNAs, showing they promote proliferation and transformation.

bioRxiv · Jun 25, 2023 · PreprintCancer Biology

Three-dimensional imaging and quantification of mouse ovarian follicles via optical coherence tomography

M. M. Amaral, A. Sun, Y. Li, C. Ren, A. B. Truong, S. Nigam, Z. Jiao, P. Wang, C. Zhou

This study uses SD-OCT to identify and quantify ovarian follicles in mice, showing agreement with histology and improved image contrast for follicle analysis.

bioRxiv · Jan 23, 2023Bioengineering

High-resolution glucose tracing and in situ imaging reveals regulated lactate production in human pancreatic β cells

F. Cuozzo, K. Viloria, A. H. Shilleh, D. Nasteska, C. Frazer-Morris, Z. Jiao, A. Boufersaoui, B. Marzullo, H. R. Smith, C. Bonner, J. Kerr-Conte, F. Pattou, R. Nano, L. Piemonti, P. R. Johnson, , D. J. Hodson

The paper uses metabolic tracing and imaging to show that human pancreatic β cells produce lactate, regulated by LDHB expression, which affects Ca2+ spiking without altering ATP/ADP levels.

bioRxiv · Dec 21, 2022 · PreprintPhysiology

Metformin protects against insulin resistance induced by high uric acid in cardiomyocytes via AMPK signaling pathways in vitro and in vivo

Z. Jiao, Y. Chen, Y. Xie, Y. Li, Z. Li

bioRxiv · Jan 29, 2021Pharmacology & Toxicology

The Preclinical Inhibitor GS441524 in Combination with GC376 Efficaciously Inhibited the Proliferation of SARS-CoV-2 in the Mouse Respiratory Tract

Y. Shi, L. Shuai, Z. Wen, C. Wang, Y. Yan, Z. Jiao, F. Guo, Z. F. Fu, H. Chen, Z.-G. Bu, G. Peng

This paper evaluates the antiviral efficacy of GS441524 and GC376 combination therapy against SARS-CoV-2 in a mouse model, showing synergistic effects and protection with low-dose combined treatment.

bioRxiv · Nov 12, 2020Microbiology

PD-L1 lncRNA splice promotes lung adenocarcinoma progression via enhancing c-Myc activity

s. Qu, Z. Jiao, G. Lu, B. Yao, T. Wang, W. Rong, J. Xu, T. Fan, X. Sun, R. Yang, J. Wang, Z. Yang, G. Xu, X. Yan, T. Wang, , K. Zen

The paper identifies PD-L1-lncRNA, a long non-coding RNA splice variant of PD-L1, that promotes lung adenocarcinoma progression by enhancing c-Myc activity.

bioRxiv · Sep 29, 2020Cancer Biology

Population Pharmacokinetics of an Anti-PD-1 Antibody Camrelizumab in Patients with Multiple tumor types and model informed dosing strategy

C. Wang, C. Sheng, G. Ma, D. Xu, X. Liu, Y. Wang, L. Zhang, C. Cui, B. Xu, Y. Song, J. Zhu, Z. Jiao

This paper performs population pharmacokinetics analysis of camrelizumab and finds no significant advantage of flat-dose or weight-based dosing regimens.

bioRxiv · Jun 30, 2020Cancer Biology

BET Bromodomain Proteins Regulate Transcriptional Reprogramming in Genetic Dilated Cardiomyopathy

A. Antolic, H. Wakimoto, Z. Jiao, J. M. Gorham, S. R. DePalma, D. A. Conner, D. Y. Lee, J. Qi, J. G. Seidman, J. E. Bradner, J. D. Brown, S. M. Haldar, C. E. Seidman, M. A. Burke

This study shows BET bromodomain proteins drive inflammatory gene networks in cardiac fibroblasts, contributing to genetic dilated cardiomyopathy, and that JQ1, a BET inhibitor, reduces disease progression.

bioRxiv · Feb 9, 2020Cell Biology

Genome-wide characterization, evolutionary analysis of WRKY genes in Cucurbitaceae species and assessment of its roles in resisting to powdery mildew disease

C. Gao, Z. Jiao, J. Sun, C. Wang, Y. Dong, S. Xiao, X. Gao, Q. Cao, L. Li, W. Li

This study identifies and characterizes WRKY genes in melon, analyzes their evolution, and assesses their role in powdery mildew resistance.

bioRxiv · Jun 19, 2018Plant Biology