R. Tamayo

This study investigates how C. difficile uses host-derived mucus for growth, metabolism, and biofilm formation, revealing metabolic shifts and potential pathogenic mechanisms.

This study shows that c-di-GMP inhibits early sporulation in C. difficile by reducing sporulation frequency and gene transcription, suggesting a regulatory role in spore formation.

This study shows that phase variation of the PdcB phosphodiesterase in C. difficile modulates intracellular c-di-GMP levels, affecting multiple phenotypes to enhance survival.

This study identifies multiple regulatory mechanisms controlling cmrRST expression in C. difficile, including phase variation, c-di-GMP signaling, and autoregulation by CmrR.

This study shows that flagellum and toxin phase variation in C. difficile affects intestinal colonization and disease development in mouse models.

This paper identifies novel metabolic drivers of virulence in C. difficile using genome-scale metabolic network analysis of two strains under different conditions.

This paper identifies a phase-variable signal transduction system in C. difficile that controls colony morphology, motility, and virulence, with implications for bacterial survival and pathogenesis.

The paper examines flagellar and toxin phase variation in C. difficile ribotype 012 isolates, finding heterogeneity in their ability to switch between motile/toxigenic and non-motile/nontoxigenic states.